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抗逆转录病毒疗法对 HIV/AIDS 患者外周调节性 CD4+/CD25hi/CD127low T 淋巴细胞的短期和长期影响。

Short- and long-term effects of antiretroviral therapy on peripheral regulatory CD4+/CD25hi/CD127low T lymphocytes in people living with HIV/AIDS.

机构信息

Wuhan University, Zhongnan Hospital, Department of Infectious Diseases, Hubei, Wuhan, China.

出版信息

Rev Inst Med Trop Sao Paulo. 2022 Feb 14;64:e11. doi: 10.1590/S1678-9946202264011. eCollection 2022.

DOI:10.1590/S1678-9946202264011
PMID:35170712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8845442/
Abstract

The effect of antiretroviral therapy (ART) on CD4+/CD25hi/CD127low T lymphocyte changes in people living with HIV/AIDS (PLWHA) is still a matter of debate. From October 2015 to December 2019, peripheral blood from 70 cases of PLWHA were collected for the detection of CD4+/CD25hi/CD127low T lymphocytes by flow cytometry. Statistical analysis was performed to detect changes of CD4+/CD25hi/CD127low T lymphocytes in patients with different duration of ART and different treatment effects. We found that the number of CD4+/CD25hi/CD127low T lymphocytes in ART-naive PLWHA were lower than those in healthy volunteers (10.3±٦.٠ cells/uL vs 31.7±8.0 cells/uL, P < 0.05). CD4+/CD25hi/CD127low T lymphocyte counts increased to 17.8±٤.٠ cells/uL 6 months post-ART and 25.0±١١.٩ cells/uL 9 months post-ART, respectively (P < 0.05). There was no significant difference in CD4+/CD25hi/CD127low T lymphocyte counts between PLWHA who reached a complete immune reconstruction after ART and healthy volunteers. The growth of CD4+/CD25hi/CD127low T lymphocyte counts in patients who had baseline CD4 > 200 cells/uL was greater than those who had baseline CD4 ≤ 200 cells/uL (12.6±٤.٦ cells/uL vs 5.6±٥.٠ cells/uL, P = 0.027). CD4+/CD25hi/CD127low T lymphocyte counts were positively correlated with CD4+ T lymphocyte counts (r = 0.923, P < 0.001) and CD4+/CD8+ ratio (r = 0.741, P < 0.001), but were negatively correlated with HIV-VL (r = -0.648, P = 0.000). In conclusion, the results of the present study showed that changes in CD4+/CD25hi/CD127low T lymphocyte counts can be used to assess the effect of ART in PLWHA.

摘要

抗逆转录病毒疗法（ART）对人类免疫缺陷病毒/艾滋病（PLWHA）患者 CD4+/CD25hi/CD127low T 淋巴细胞变化的影响仍存在争议。从 2015 年 10 月至 2019 年 12 月，采集了 70 例 PLWHA 的外周血，通过流式细胞术检测 CD4+/CD25hi/CD127low T 淋巴细胞。对不同 ART 时间和不同治疗效果患者的 CD4+/CD25hi/CD127low T 淋巴细胞变化进行了统计学分析。结果发现，ART 初治 PLWHA 的 CD4+/CD25hi/CD127low T 淋巴细胞数量低于健康志愿者（10.3±6.0 细胞/μL vs 31.7±8.0 细胞/μL，P＜0.05）。ART 后 6 个月，CD4+/CD25hi/CD127low T 淋巴细胞计数增加至 17.8±4.0 细胞/μL，ART 后 9 个月增加至 25.0±11.9 细胞/μL（P＜0.05）。ART 后完全重建免疫的 PLWHA 与健康志愿者的 CD4+/CD25hi/CD127low T 淋巴细胞计数无差异。基线 CD4＞200 细胞/μL 的患者 CD4+/CD25hi/CD127low T 淋巴细胞计数的增长大于基线 CD4≤200 细胞/μL 的患者（12.6±4.6 细胞/μL vs 5.6±5.0 细胞/μL，P=0.027）。CD4+/CD25hi/CD127low T 淋巴细胞计数与 CD4+T 淋巴细胞计数（r=0.923，P＜0.001）和 CD4+/CD8+比值（r=0.741，P＜0.001）呈正相关，与 HIV-VL（r=-0.648，P=0.000）呈负相关。综上所述，本研究结果表明，CD4+/CD25hi/CD127low T 淋巴细胞计数的变化可用于评估 PLWHA 的 ART 疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/78d4ea3a6a99/1678-9946-rimtsp-64-S1678-9946202264011-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/3cb6a1f79d5f/1678-9946-rimtsp-64-S1678-9946202264011-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/e2422132c703/1678-9946-rimtsp-64-S1678-9946202264011-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/78d4ea3a6a99/1678-9946-rimtsp-64-S1678-9946202264011-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/3cb6a1f79d5f/1678-9946-rimtsp-64-S1678-9946202264011-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/e2422132c703/1678-9946-rimtsp-64-S1678-9946202264011-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae04/8845442/78d4ea3a6a99/1678-9946-rimtsp-64-S1678-9946202264011-gf03.jpg

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本文引用的文献

[1]
Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders.

J Leukoc Biol. 2020-1-22

[2]
The detection and clinical significance of peripheral regulatory CD4CD25CD127 T cells in patients with non-small cell lung cancer.

Clin Transl Oncol. 2019-2-20

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Regulatory T cells in retroviral infections.

PLoS Pathog. 2018-2-15

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Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection.

BMC Immunol. 2017-12-16

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Update of the DHHS antiretroviral treatment guidelines.

AIDS Rev. 2014

[6]
CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection.

Front Immunol. 2013-7-30

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High frequency of regulatory T cells among HIV type 1-infected men who have sex with men correlates with disease progression.

Chin Med J (Engl). 2013

[8]
The split personality of regulatory T cells in HIV infection.

Blood. 2012-10-4

[9]
Homeostasis and function of regulatory T cells in HIV/SIV infection.

J Virol. 2012-7-18

[10]
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.

PLoS One. 2011-12-5

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