Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Histol Histopathol. 2022 May;37(5):475-481. doi: 10.14670/HH-18-439. Epub 2022 Feb 18.
Colorectal cancer is one of the most prevalent types of tumors worldwide. P16ᴵᴺᴷ⁴ᵃ is a widely used immunohistochemical marker for high-risk HPV infection. The purpose of this study is to explore the relationship between P16 expression as an indicator of HPV infection and colorectal cancer in Egyptian patients, as well as its association with histopathological characteristics.
The study was performed on 59 cases of colorectal carcinoma cases and 30 specimens of normal colonic mucosa.
p16 protein was detected in 22% (13 of 59) of patients with colorectal carcinoma. No evidence of P16 expression in all 30 cases of non-neoplastic colonic mucosa was found. More frequent expression of P16 was seen in distal carcinomas.
our study demonstrated that P16 protein is expressed in a reasonable percent of colorectal carcinoma cases, suggesting a role of HPV in colorectal carcinogenesis. The present study highlights the role of p16 protein expression which is important in the pathogenesis in colorectal carcinoma, especially regarding distal tumors.
结直肠癌是全球最常见的肿瘤类型之一。P16ᴵᴺᴷ⁴ᵃ 是一种广泛用于高危 HPV 感染的免疫组织化学标志物。本研究旨在探讨 P16 表达作为 HPV 感染的指标与埃及患者结直肠癌之间的关系，以及其与组织病理学特征的关系。
本研究对 59 例结直肠癌病例和 30 例正常结肠黏膜标本进行了研究。
在 59 例结直肠癌患者中，检测到 p16 蛋白的占 22%（13 例）。在所有 30 例非肿瘤性结肠黏膜中均未发现 P16 表达。远端癌中 P16 的表达更为频繁。
我们的研究表明，P16 蛋白在相当一部分结直肠癌病例中表达，提示 HPV 在结直肠癌发生中的作用。本研究强调了 p16 蛋白表达在结直肠癌发病机制中的重要作用，尤其是在远端肿瘤中。
