Xie Shanshan, Fan Wenguo, He Hongwen, Huang Fang
Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, People's Republic of China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, People's Republic of China.
J Pain Res. 2020 Feb 7;13:331-343. doi: 10.2147/JPR.S228577. eCollection 2020.
Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms.
褪黑素是一种多效性激素，主要由脊椎动物的松果体合成和分泌。褪黑素是昼夜节律和季节性节律的内源性调节因子。褪黑素参与许多生理和病理生理过程，具有抗氧化、抗肿瘤、抗炎和免疫调节特性。越来越多的证据表明，褪黑素通过多种机制在疼痛调节中发挥重要作用。在本综述中，我们研究了褪黑素在各种动物模型和疼痛综合征患者中对疼痛调节的最新证据以及潜在的细胞机制。
