Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Eur Rev Med Pharmacol Sci. 2022 Feb;26(3):828-845. doi: 10.26355/eurrev_202202_27991.
Sutures are used to facilitate wound healing and play an important role in ensuring the success of surgical interventions in healthcare facilities. Suture-associated surgical site infection (SSI) may develop when bacterial contaminants colonize the suture surface and establish biofilms that are highly resistant to antibiotic treatment. The outcome of SSI affects postoperative care, leading to high rates of morbidity and mortality, prolonged hospitalization, and increased financial burden. Antimicrobial sutures coated with antiseptics such as triclosan and chlorhexidine have been used to minimize the occurrence of SSI. However, as the efficacy of antiseptic-based sutures may be affected due to the emergence of resistant strains, new approaches for the development of alternative antimicrobial sutures are necessary. This review provides an update and outlook of various approaches in the design and development of antimicrobial sutures. Attaining a zero SSI rate will be possible with the advancement in suturing technology and implementation of good infection control practice in clinical settings.
缝线被用于促进伤口愈合，并在确保医疗保健设施中的手术干预成功方面发挥着重要作用。当细菌污染物定植在缝线表面并形成对抗生素治疗高度耐药的生物膜时，可能会发生与缝线相关的手术部位感染（SSI）。SSI 的结果会影响术后护理，导致高发病率和死亡率、延长住院时间和增加经济负担。用抗菌剂（如三氯生和洗必泰）涂覆的抗菌缝线已被用于最大限度地减少 SSI 的发生。然而，由于抗药性菌株的出现，基于防腐剂的缝线的功效可能受到影响，因此需要开发替代抗菌缝线的新方法。本综述提供了设计和开发抗菌缝线的各种方法的最新进展和展望。随着缝合技术的进步和临床实践中良好感染控制措施的实施，实现零 SSI 率将成为可能。
