Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
J Parkinsons Dis. 2022;12(3):967-974. doi: 10.3233/JPD-213007.
The prodromal phase of Parkinson's disease (PD) can last up to 20 years and is characterized by a variety of non-motor symptoms.
To determine the prevalence of a selection of non-motor symptoms known to be associated with an increased risk of developing PD in a late middle-aged population-based sample and to determine their association with motor function.
At a mean age of 60.3 years, 775 subjects were recruited from the Longitudinal Aging Study Amsterdam (LASA). Hyposmia, cognitive impairment, patient-reported constipation, possible REM-sleep behavior disorder, depression, and anxiety were indexed as known PD risk factors. Additionally, 1) the PD screening questionnaire, 2) four physical performance tests, and 3) a functional limitations questionnaire, were used to determine whether the presence of two or more PD risk factors was associated with reduced motor function.
The prevalence of single risk factors ranged between 3 and 13%. Approximately 11% of subjects had two or more PD risk factors. Motor functioning of subjects with two or more PD risk factors was significantly worse than performance of subjects without or with a single risk factor (all p values≤0.001).
Approximately 11% of the late middle-aged population has two or more known PD risk factors. Among these subjects self-perceived PD symptoms and reduced physical performance are more prevalent, suggesting that at least some of these subjects may be in the prodromal phase of PD.
帕金森病（PD）的前驱期可持续长达 20 年，其特征是存在多种非运动症状。
在一个中老年人群中，确定与 PD 发生风险增加相关的一系列已知非运动症状的流行率，并确定它们与运动功能的关系。
在平均年龄为 60.3 岁时，从阿姆斯特丹纵向老龄化研究（LASA）中招募了 775 名受试者。嗅觉减退、认知障碍、患者自述的便秘、可能的 REM 睡眠行为障碍、抑郁和焦虑被确定为已知的 PD 危险因素。此外，还使用 1）PD 筛查问卷、2）四项身体机能测试和 3）功能障碍问卷，来确定是否存在两个或更多 PD 危险因素与运动功能下降有关。
单一危险因素的患病率在 3%至 13%之间。大约 11%的受试者有两个或更多 PD 危险因素。有两个或更多 PD 危险因素的受试者的运动功能明显比没有或只有一个危险因素的受试者差（所有 p 值均≤0.001）。
大约 11%的中老年人群有两个或更多的已知 PD 危险因素。这些受试者中自我感知的 PD 症状和身体机能下降更为普遍，这表明其中至少一些受试者可能处于 PD 的前驱期。
