Rzepczyk C M, Bishop C J, Atwell R B
Z Parasitenkd. 1986;72(2):241-9. doi: 10.1007/BF00931151.
When microfilariae (Mf) of Dirofilaria immitis, both uterine and systemic, were incubated in an in vitro cytotoxicity assay with neutrophils and sera from dogs with occult infections, some Mf remained free of adherent cells and consequently evaded cytotoxicity. The ability to evade cytotoxicity could not be related to the age of the Mf, and host albumin was not detected on any Mf, either uterine or systemic. However, it was shown that some Mf failed to bind IgM, IgG and C3 when incubated with occult sera. It is suggested that the ability of some Mf to evade serum-dependent, neutrophil-mediated cytotoxicity in vitro was related to differences in their antigenicity.
当犬恶丝虫的子宫内微丝蚴和全身微丝蚴在体外细胞毒性试验中与隐性感染犬的中性粒细胞和血清一起孵育时，一些微丝蚴未附着细胞，从而逃避了细胞毒性。逃避细胞毒性的能力与微丝蚴的年龄无关，在任何子宫内或全身的微丝蚴上均未检测到宿主白蛋白。然而，研究表明，一些微丝蚴与隐性血清孵育时未能结合IgM、IgG和C3。有人提出，一些微丝蚴在体外逃避血清依赖性、中性粒细胞介导的细胞毒性的能力与其抗原性差异有关。
