Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Mitochondrion. 2022 May;64:1-18. doi: 10.1016/j.mito.2022.02.004. Epub 2022 Feb 16.
Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and changes in calcium handling are associated with neurodegenerative diseases; however, different sites and types of mitochondrial dysfunction are linked to distinct neuropathologies. Understanding the causal or correlative relationship between changes in mitochondria and neuropathology will lead to new therapeutic strategies. Here, we summarize the evidence of site-specific mitochondrial dysfunction and mitochondrial-related clinical trials for neurodegenerative diseases. We further discuss potential therapeutic approaches, such as mitochondrial transplantation, restoration of mitochondrial function, and pharmacological alleviation of mitochondrial dysfunction.
线粒体对于神经元的存活至关重要，线粒体功能障碍是神经退行性变的标志。线粒体能量产生的丧失、氧化应激和钙处理的改变与神经退行性疾病有关；然而，不同部位和类型的线粒体功能障碍与不同的神经病理学有关。了解线粒体变化与神经病理学之间的因果关系或相关性将导致新的治疗策略。在这里，我们总结了特定部位线粒体功能障碍和与神经退行性疾病相关的线粒体临床试验的证据。我们还进一步讨论了潜在的治疗方法，如线粒体移植、恢复线粒体功能和药物缓解线粒体功能障碍。
