调节神经退行性疾病中线粒体功能的新疗法。
New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.
机构信息
Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States.
University of Kansas School of Medicine, University of Kansas Alzheimer's Disease Center MS 6002, 3901 Rainbow Blvd, Kansas City, KS 66160. United States.
出版信息
Curr Pharm Des. 2017;23(5):731-752. doi: 10.2174/1381612822666161230144517.
BACKGROUND
Mitochondrial function and energy metabolism are impaired in neurodegenerative diseases. There is evidence for these functional declines both within the brain and systemically in Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Due to these observations, therapeutics targeted to alter mitochondrial function and energy pathways are increasingly studied in pre-clinical and clinical settings.
METHODS
The goal of this article was to review therapies with specific implications on mitochondrial energy metabolism published through May 2016 that have been tested for treatment of neurodegenerative diseases.
RESULTS
We discuss implications for mitochondrial dysfunction in neurodegenerative diseases and how this drives new therapeutic initiatives.
CONCLUSION
Thus far, treatments have achieved varying degrees of success. Further investigation into the mechanisms driving mitochondrial dysfunction and bioenergetic failure in neurodegenerative diseases is warranted.
背景
线粒体功能和能量代谢在神经退行性疾病中受损。在阿尔茨海默病、帕金森病和肌萎缩性侧索硬化症中，无论是在大脑内还是在全身范围内，都有这些功能下降的证据。由于这些观察结果，针对改变线粒体功能和能量途径的治疗方法在临床前和临床环境中得到了越来越多的研究。
方法
本文的目的是回顾 2016 年 5 月之前发表的针对线粒体能量代谢的具有特定影响的治疗方法，并对其治疗神经退行性疾病的效果进行测试。
结果
我们讨论了线粒体功能障碍在神经退行性疾病中的意义，以及它如何推动新的治疗方法。
结论
到目前为止，这些治疗方法已经取得了不同程度的成功。进一步研究神经退行性疾病中线粒体功能障碍和生物能衰竭的驱动机制是有必要的。
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