Department of Biochemistry and Molecular Biology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Department of Biochemistry and Molecular Biology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Gene. 2022 May 15;822:146352. doi: 10.1016/j.gene.2022.146352. Epub 2022 Feb 17.
Metallochaperones are a class of unique protein families that was originally found to interact with cellular metal ions by metal delivery to specific target proteins such as metal enzymes. Recently, some members of metallochaperones receive much attention owning to their multi-biological functions in mediating plant growth, development and biotic or abiotic stress responses, particularly in the aspects of metal transport and accumulation in plants. For example, some non-essential toxic heavy metals (e.g. cadmium and mercury) accumulating in farmland due to the industrial and agronomic activities, are a constant threat to crop production, food safety and human health. Digging genetic resources and functional genes like metallochaperones is critical for understanding the metal detoxification in plants, and may help develop cleaner crops with minimal toxic metals in leafy vegetables and grains, or plants for metal-polluted soil phytoremediation. In this review, we highlight the current advancement of the research on functions of metallochaperones in metal accumulation, detoxification and homeostasis. We also summarize the recent progress of the research on the critical roles of the metal-binding proteins in regulating plant responses to some other biological processes including plant growth, development, pathogen stresses, and abiotic stresses such salt, drought, cold and light. Finally, an additional capacity of some members of metallochaperones involved in the resistance to the pathogen attack and possibly regulatory roles was reviewed.
金属伴侣蛋白是一类独特的蛋白家族，最初被发现通过将金属离子递送到特定的靶蛋白（如金属酶）来与细胞内的金属离子相互作用。最近，一些金属伴侣蛋白的成员因其在介导植物生长、发育和生物或非生物胁迫反应方面的多种生物学功能而受到广泛关注，特别是在植物中金属运输和积累方面。例如，由于工业和农业活动，农田中积累了一些非必需的有毒重金属（如镉和汞），这对作物生产、食品安全和人类健康构成了持续威胁。挖掘金属伴侣蛋白等遗传资源和功能基因对于理解植物中的金属解毒至关重要，并且可能有助于开发出叶菜类蔬菜和谷物中含毒金属最少的清洁作物，或用于受污染土壤植物修复的植物。在这篇综述中，我们强调了金属伴侣蛋白在金属积累、解毒和稳态方面的功能研究的最新进展。我们还总结了金属结合蛋白在调节植物对一些其他生物学过程（包括植物生长、发育、病原体胁迫以及盐、干旱、寒冷和光照等非生物胁迫）的反应方面的关键作用的最新研究进展。最后，我们还综述了一些金属伴侣蛋白成员参与病原体攻击抗性的额外能力及其可能的调节作用。
