Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, Beijing 100029, China.
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Biomed Pharmacother. 2022 Apr;148:112726. doi: 10.1016/j.biopha.2022.112726. Epub 2022 Feb 17.
Cardiovascular disease (CVD) is one of the leading causes of death and disability, and has always been a hotspot in clinical and scientific research. The illness brings a heavy economic burden and causes psychological pressure on society and families. The pathogenesis of CVD is complex and has not yet been fully elucidated. Mitochondria provide energy for cardiovascular function. cAMP signaling is closely related to the mechanism of action of mitochondria. Epac, an important effector of cAMP, is involved in a variety of physiopathological mechanisms of CVD. Epac acts on a variety of pathways, including ion level regulation, cardiac hypertrophy, cardiac fibrosis, cardiomyocyte apoptosis, and angiogenesis. In this article, we systematically discuss the mechanism of action of Epac in CVDs to provide (i) ideas for the treatment of CVDs such as arrhythmia and heart failure and (ii) a basis for studying biological pathways and carrying out targeted drug research. Although some of the studied mechanisms are inconsistent, they also illustrate the complexity and importance of the effects of Epac.
心血管疾病（CVD）是导致死亡和残疾的主要原因之一，一直是临床和科学研究的热点。这种疾病给社会和家庭带来了沉重的经济负担和心理压力。CVD 的发病机制复杂，尚未完全阐明。线粒体为心血管功能提供能量。cAMP 信号与线粒体的作用机制密切相关。Epac 是 cAMP 的重要效应因子，参与 CVD 的多种生理病理机制。Epac 作用于多种途径，包括离子水平调节、心肌肥厚、心肌纤维化、心肌细胞凋亡和血管生成。本文系统地讨论了 Epac 在 CVD 中的作用机制，为心律失常和心力衰竭等 CVD 的治疗提供了思路，并为研究生物途径和开展靶向药物研究提供了依据。尽管一些研究的机制不一致，但它们也说明了 Epac 作用的复杂性和重要性。
