Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.
COVID-19 National Epidemiology Cell, UK Health Security Agency, London, United Kingdom.
J Infect Dis. 2022 Sep 13;226(5):808-811. doi: 10.1093/infdis/jiac063.
To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77-.94), hospital admission or emergency care attendance (aHR = 0.87; 95% CI, .81-.94), and COVID-19 mortality (aHR = 0.85; 95% CI, .71-1.03). The results indicate that the risks of hospitalization and mortality are similar or lower for AY.4.2 compared to cases with other delta sublineages.
为了研究 SARS-CoV-2 德尔塔变体的 AY.4.2 亚系是否与住院和死亡率风险相关，这些风险与非 AY.4.2 德尔塔风险不同，我们基于常规医疗数据集的关联，对英国经测序确认的 COVID-19 病例进行了回顾性队列研究。我们使用分层 Cox 回归估计了住院（调整后危险比[aHR] = 0.85；95%置信区间[CI]，0.77-0.94）、住院或急诊就诊（aHR = 0.87；95% CI，0.81-0.94）和 COVID-19 死亡率（aHR = 0.85；95% CI，0.71-1.03）的调整后危险比[aHR]。结果表明，与其他德尔塔亚系病例相比，AY.4.2 的住院和死亡率风险相似或更低。
