Occupational Dermatology Department, Hospital Fremap, Madrid, Spain.
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Contact Dermatitis. 2022 Jul;87(1):53-61. doi: 10.1111/cod.14079. Epub 2022 Mar 22.
Sensitization to acrylates is a concern in the occupational/environmental dermatology field.
To describe an occupational allergic contact dermatitis (ACD) outbreak from a smartphone screen protector glue.
Thirteen affected workers of a chain store selling phone screen protectors were investigated in five Spanish dermatology departments. The glue datasheet and label were assessed. A chemical analysis of the glue was performed. Based on this, some patients underwent additional testing.
All patients (all female, mean age: 25) had severe fingertip dermatitis. The datasheet/label indicated that the glue contained isobornyl acrylate (IBOA), a "photoinitiator" and polyurethane oligomer. The company informed us that the ingredients were polyurethane acrylate, "methacrylate" (unspecified), acrylic acid, hydroxyethyl methacrylate, propylmethoxy siloxane, and photoinitiator 184. Isobornyl acrylate (or IBOA) and N,N-dimethylacrylamide (DMAA) were patch tested in eight and two cases, respectively, with negative results. A chemical analysis revealed 4-acryloylmorpholine (ACMO); isobornyl methacrylate (IBMA), and lauryl acrylate in one glue sample. Seven patients were patch tested with dilutions of the identified substances and six of seven were positive for ACMO 0.5% pet.
An outbreak of occupational ACD, likely from ACMO in a glue is described. Further investigations are needed to corroborate the role played by each compound identified in the chemical analyses.
丙烯酸酯类物质致敏是职业/环境皮肤病学领域关注的问题。
描述一种智能手机屏幕保护膜胶引起的职业性过敏性接触性皮炎(ACD)暴发。
在西班牙五个皮肤科部门调查了一家销售手机屏幕保护膜连锁店的 13 名受影响工人。评估了胶的数据表和标签。对胶进行了化学分析。在此基础上,一些患者进行了额外的测试。
所有患者(均为女性,平均年龄 25 岁)均患有严重的指尖性皮炎。数据表/标签表明,胶含有异冰片丙烯酸酯(IBOA),一种“光引发剂”和聚氨酯低聚物。公司告知我们,成分是聚氨酯丙烯酸酯、“甲基丙烯酸酯”(未指定)、丙烯酸、羟乙基甲基丙烯酸酯、丙基甲氧基硅烷和光引发剂 184。在 8 例和 2 例患者中分别用异冰片丙烯酰胺(或 IBOA)和 N,N-二甲基丙烯酰胺(DMAA)进行斑贴试验,结果均为阴性。化学分析显示,一种胶样中含有 4-丙烯酰吗啉(ACMO)、异冰片基甲基丙烯酸酯(IBMA)和月桂基丙烯酸酯。对七种物质的稀释液进行了七种患者的斑贴试验,其中六种对 ACMO 0.5% pet 呈阳性。
描述了一种由胶中 ACMO 引起的职业性 ACD 暴发。需要进一步调查以证实化学分析中鉴定的每种化合物所起的作用。