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Single-cell transcriptomics reveals pathogenic dysregulation of previously unrecognised chondral stem/progenitor cells in children with microtia.

作者信息

Ma Jing, Zhang Yu, Yan Zijun, Wu Peixuan, Li Chenlong, Yang Run, Lu Xinyu, Chen Xin, He Aijuan, Fu Yaoyao, Ma Duan, Tian Weidong, Zhang Tianyu

机构信息

Department of Facial Plastic and Reconstructive Surgery, ENT Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.

State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, Department of Computational Biology, School of Life Sciences, Fudan University, Shanghai, China.

出版信息

Clin Transl Med. 2022 Feb;12(2):e702. doi: 10.1002/ctm2.702.

DOI:10.1002/ctm2.702
PMID:35184397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8858629/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/946b5e581b0a/CTM2-12-e702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/693f7164c169/CTM2-12-e702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/b5392d511da5/CTM2-12-e702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/774e209cfe3b/CTM2-12-e702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/946b5e581b0a/CTM2-12-e702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/693f7164c169/CTM2-12-e702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/b5392d511da5/CTM2-12-e702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/774e209cfe3b/CTM2-12-e702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a67d/8858629/946b5e581b0a/CTM2-12-e702-g002.jpg

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Linking peripheral CD8 single-cell transcriptomic characteristics of mood disorders underlying with the pathological mechanism.将情绪障碍潜在的外周CD8单细胞转录组特征与病理机制相联系。
Clin Transl Med. 2021 Jul;11(7):e489. doi: 10.1002/ctm2.489.
3
Aging Atlas: a multi-omics database for aging biology.
用于耳廓重建的软骨膜与软骨的集成仿生生物打印
Bioact Mater. 2025 Feb 14;48:100-117. doi: 10.1016/j.bioactmat.2025.02.011. eCollection 2025 Jun.
4
HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia.维甲酸途径抑制诱导的HOXB6下调导致小耳畸形中软骨细胞增殖抑制和凋亡。
Genes Dis. 2024 Jun 25;12(3):101367. doi: 10.1016/j.gendis.2024.101367. eCollection 2025 May.
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