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HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia.

作者信息

Yang Run, Chen Xin, Wu Siyi, Li Chenlong, Chen Ying, Fu Yaoyao, He Aijuan, Ma Duan, Ma Jing, Zhang Tianyu

机构信息

ENT Institute, Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.

Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

出版信息

Genes Dis. 2024 Jun 25;12(3):101367. doi: 10.1016/j.gendis.2024.101367. eCollection 2025 May.

DOI:10.1016/j.gendis.2024.101367
PMID:39897132
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786823/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/1e5a24f8dcaf/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/62ea21a65571/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/46c789270f4a/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/0df00a79f190/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/cee56b63c190/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/de0be36c7a53/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/1e5a24f8dcaf/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/62ea21a65571/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/46c789270f4a/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/0df00a79f190/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/cee56b63c190/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/de0be36c7a53/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11786823/1e5a24f8dcaf/figs5.jpg

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HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia.维甲酸途径抑制诱导的HOXB6下调导致小耳畸形中软骨细胞增殖抑制和凋亡。
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本文引用的文献

1
Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics.通过转录组学和蛋白质组学分析鉴定非综合征性小耳畸形中的关键基因
ACS Omega. 2022 May 13;7(20):16917-16927. doi: 10.1021/acsomega.1c07059. eCollection 2022 May 24.
2
Single-cell transcriptomics reveals pathogenic dysregulation of previously unrecognised chondral stem/progenitor cells in children with microtia.单细胞转录组学揭示了小耳畸形患儿中先前未被识别的软骨干细胞/祖细胞的致病失调。
Clin Transl Med. 2022 Feb;12(2):e702. doi: 10.1002/ctm2.702.
3
Identification of a second HOXA2 nonsense mutation in a family with autosomal dominant non-syndromic microtia and distinctive ear morphology.
在一个患有常染色体显性非综合征性小耳畸形且耳部形态独特的家族中鉴定出第二个HOXA2无义突变。
Clin Genet. 2017 May;91(5):774-779. doi: 10.1111/cge.12845. Epub 2016 Sep 13.
4
Microtia: epidemiology and genetics.小耳畸形：流行病学与遗传学。
Am J Med Genet A. 2012 Jan;158A(1):124-39. doi: 10.1002/ajmg.a.34352. Epub 2011 Nov 21.
5
AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells.AGN193109是一种在人宫颈外上皮细胞中对类视黄醇作用有高效拮抗作用的物质。
J Biol Chem. 1996 May 24;271(21):12209-12. doi: 10.1074/jbc.271.21.12209.