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Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma.

作者信息

Li Shenglan, Chen Jinyi, Fan Yaqiong, Wang Ce, Wang Can, Zheng Xiaohong, Chen Feng, Li Wenbin

机构信息

Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

出版信息

Signal Transduct Target Ther. 2022 Feb 21;7(1):49. doi: 10.1038/s41392-021-00869-w.

DOI:10.1038/s41392-021-00869-w
PMID:35185151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8858958/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a942/8858958/8a5e1bde364a/41392_2021_869_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a942/8858958/8a5e1bde364a/41392_2021_869_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a942/8858958/8a5e1bde364a/41392_2021_869_Fig1_HTML.jpg

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Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma.脂质体厚朴酚通过调节ERK/p38-MAPK信号通路和抑制自噬，诱导人髓母细胞瘤中ROS介导的细胞凋亡。
Signal Transduct Target Ther. 2022 Feb 21;7(1):49. doi: 10.1038/s41392-021-00869-w.
2
Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.厚朴酚通过活性氧介导的p53/PI3K/Akt/mTOR信号通路调控诱导恶性胶质瘤细胞发生自噬性细胞死亡。
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3
Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo.和厚朴酚通过 ROS/ERK1/2 信号通路诱导人骨肉瘤细胞体外和体内凋亡和自噬。
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Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction.厚朴酚通过线粒体功能障碍诱导白色念珠菌中活性氧介导的细胞凋亡。
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Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration.和厚朴酚通过激活 PI3K/Akt/mTOR 和内质网应激/ERK1/2 信号通路以及抑制细胞迁移诱导神经母细胞瘤细胞自噬。
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Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells.霍诺醇通过活性氧的产生诱导半胱天冬酶非依赖性副凋亡，伴随着白血病细胞的凋亡。
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Regulation of LC3B levels by ubiquitination and proteasomal degradation.LC3B 水平的泛素化和蛋白酶体降解调节。
Autophagy. 2020 Feb;16(2):382-384. doi: 10.1080/15548627.2019.1709766. Epub 2020 Jan 2.
2
Ginsenoside Compound K Induces Ros-Mediated Apoptosis and Autophagic Inhibition in Human Neuroblastoma Cells In Vitro and In Vivo.人参皂苷Compound K 通过诱导 ROS 介导的细胞凋亡和自噬抑制来杀伤人神经母细胞瘤细胞。
Int J Mol Sci. 2019 Sep 1;20(17):4279. doi: 10.3390/ijms20174279.
3
Lysosomal membrane permeabilization and cell death.
血小板膜包裹的载茶多酚纳米粒吸入显著减轻哮喘炎症。
Respir Res. 2024 Aug 17;25(1):311. doi: 10.1186/s12931-024-02947-3.
4
Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways.草本植物化合物作为抗癌剂的前景：基于分子途径的全面综述
Front Pharmacol. 2024 Jul 22;15:1387866. doi: 10.3389/fphar.2024.1387866. eCollection 2024.
5
Suppressing MTERF3 inhibits proliferation of human hepatocellular carcinoma via ROS-mediated p38 MAPK activation.抑制 MTERF3 通过 ROS 介导的 p38 MAPK 激活抑制人肝癌细胞的增殖。
Commun Biol. 2024 Jan 5;7(1):18. doi: 10.1038/s42003-023-05664-7.
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Nanotechnology-Based Drug Delivery Systems for Honokiol: Enhancing Therapeutic Potential and Overcoming Limitations.基于纳米技术的霍诺酚药物传递系统：提高治疗潜力和克服局限性。
Int J Nanomedicine. 2023 Nov 13;18:6639-6665. doi: 10.2147/IJN.S431409. eCollection 2023.
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Honokiol in glioblastoma recurrence: a case report.厚朴酚用于胶质母细胞瘤复发：一例报告
Front Neurol. 2023 Jun 22;14:1172860. doi: 10.3389/fneur.2023.1172860. eCollection 2023.
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Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step.和厚朴酚在细胞培养中通过进入后步骤抑制 SARS-CoV-2 复制。
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Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells.和厚朴酚通过调节 miR-21/PTEN/PI3K/AKT 信号通路抑制人骨肉瘤细胞增殖并诱导其凋亡。
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Intertumoral Heterogeneity within Medulloblastoma Subgroups.髓母细胞瘤亚组内的肿瘤间异质性。
Cancer Cell. 2017 Jun 12;31(6):737-754.e6. doi: 10.1016/j.ccell.2017.05.005.