Mahmud Mazaya, Ahem Amin, Bastion Mae-Lynn Catherine, Omar Rokiah, Nawi Azmawati Mohammed, Razak Norsyariza, Satali Adib Mohd, Khialdin Safinaz Mohd, Din Norshamsiah Md
Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Department of Ophthalmology, Faculty of Medicine, Universiti Putra Malaysia, Seri Kembangan, Malaysia.
Front Cell Neurosci. 2022 Feb 2;16:800065. doi: 10.3389/fncel.2022.800065. eCollection 2022.
The aim of this study was to evaluate the choroidal and photoreceptor thickness in highly myopic eyes and its correlation with visual acuity.
This is a cross-sectional, observational study involving 57 eyes of 57 highly myopic subjects [spherical equivalent ≥ -6 diopters (D) or axial length ≥ 26 mm] seen in a tertiary institutional center. Eyes with any clinical evidence of maculopathy or amblyopia were excluded. All subjects underwent a refraction assessment, visual acuity, axial length measurement using the IOL Master, and full ocular assessment. Eyes were imaged using Spectralis Optical Coherence Tomography by one experienced operator. Two independent investigators manually measured subfoveal choroidal thickness (SFCT) and foveal photoreceptor thickness (FPT).
The mean SFCT was 195.88 ± 87.63 μm (range: 32-373) and mean FPT was 96.68 ± 11.23 μm (range: 67-100), after correction for ocular magnification. The best corrected visual acuity (BCVA) in LogMAR was negatively correlated with SFCT ( = -0.510, = 0.001) and FPT ( = -0.397, = 0.002) and positively correlated with age ( = 0.418, = 0.001) and axial length ( = 0.551, = 0.001). Multiple linear regression analysis showed that age, axial length, and corrected FPT were significant risk factors for poorer BCVA ( = 0.021, < 0.001, and 0.02, respectively).
FPT, age, and axial length are significant moderate predictive factors for poorer visual acuity in highly myopic eyes without myopic maculopathy. Thinner SFCT does not translate into poorer vision.
本研究旨在评估高度近视眼中脉络膜和光感受器的厚度及其与视力的相关性。
这是一项横断面观察性研究，纳入了在三级机构中心就诊的57例高度近视患者的57只眼[等效球镜度≥-6屈光度（D）或眼轴长度≥26mm]。排除有任何黄斑病变或弱视临床证据的眼。所有受试者均接受验光评估、视力检查、使用IOL Master测量眼轴长度以及全面的眼部评估。由一名经验丰富的操作人员使用Spectralis光学相干断层扫描对眼睛进行成像。两名独立研究人员手动测量黄斑中心凹下脉络膜厚度（SFCT）和黄斑中心凹光感受器厚度（FPT）。
校正眼放大率后，平均SFCT为195.88±87.63μm（范围：32 - 373），平均FPT为96.68±11.23μm（范围：67 - 100）。LogMAR视力表中的最佳矫正视力（BCVA）与SFCT呈负相关（r = -0.510，P = 0.001）和FPT呈负相关（r = -0.397，P = 0.002），与年龄呈正相关（r = 0.418，P = 0.001）和眼轴长度呈正相关（r = 0.551，P = 0.001）。多元线性回归分析显示，年龄、眼轴长度和校正后的FPT是BCVA较差的显著危险因素（分别为β = 0.021，P < 0.001和0.02）。
在没有近视性黄斑病变的高度近视眼中，FPT、年龄和眼轴长度是视力较差的显著中度预测因素。较薄的SFCT并不意味着视力较差。
