Gyawali Parash, Jnawali Ashutosh, Kharal Anish, Subedi Manish, Kandel Sandeep, Puri Prajjol Raj, Paudel Nabin
B. P. Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal.
College of Optometry, The University of Houston, Houston, Texas, USA.
J Ophthalmol. 2023 May 11;2023:2209496. doi: 10.1155/2023/2209496. eCollection 2023.
Evidence suggests that choroid is thinner in myopes as compared to nonmyopes. However, choroidal thickness varies with the refractive error, age, axial length, and ethnicity. The purpose of this study was to determine the subfoveal choroidal thickness (SFCT) in high myopic Nepalese subjects and to investigate its association with the mean spherical equivalent refractive error (MSE), axial length, and age.
Ninety-two eyes of 92 high myopic subjects (MSE ≤ -6 diopters) and 83 eyes of 83 emmetropic subjects (MSE: 0.00 Diopters) were included in the study. SFCT was assessed using spectral domain optical coherence tomography, and the axial length was measured using partial coherence interferometry. SFCT was measured manually using the inbuilt tool within the imaging software.
SFCT in the high myopic subjects was significantly thinner (mean ± SD: 224.17 ± 68.91 m) as compared to the emmetropic subjects (353.24 ± 65.63 m) (mean difference, 127.76 ± 130.80 m, and < 0.001). In high myopic subjects, there was a significant negative correlation of choroidal thickness with the axial length (rho = -0.75; < 0.001) and MSE (rho = -0.404; < 0.01). Regression analysis demonstrated a decrease of choroidal thickness by 40.32 m ( < 0.001) for every 1 millimeter increase in the axial length and by 11.65 m ( < 0.001) for every 1 diopter increase in the MSE.
High myopic Nepalese subjects had significantly thinner choroid as compared to emmetropes. The MSE and axial length were inversely correlated with the SFCT. Age had no effect on SFCT in this study. These findings may have implications in interpreting choroidal thickness values in clinical and epidemiological studies in myopes, especially in the south Asian population.
有证据表明，与非近视者相比，近视者的脉络膜更薄。然而，脉络膜厚度会因屈光不正、年龄、眼轴长度和种族而有所不同。本研究的目的是确定高度近视尼泊尔受试者的黄斑中心凹下脉络膜厚度（SFCT），并研究其与平均球镜等效屈光不正（MSE）、眼轴长度和年龄的关系。
本研究纳入了92名高度近视受试者（MSE≤-6屈光度）的92只眼和83名正视受试者（MSE：0.00屈光度）的83只眼。使用光谱域光学相干断层扫描评估SFCT，并使用部分相干干涉测量法测量眼轴长度。使用成像软件中的内置工具手动测量SFCT。
与正视受试者（353.24±65.63μm）相比，高度近视受试者的SFCT明显更薄（平均值±标准差：224.17±68.91μm）（平均差异为127.76±130.80μm，P<0.001）。在高度近视受试者中，脉络膜厚度与眼轴长度（rho=-0.75；P<0.001）和MSE（rho=-0.404；P<0.01）呈显著负相关。回归分析表明，眼轴长度每增加1毫米，脉络膜厚度减少40.32μm（P<0.001）；MSE每增加1屈光度，脉络膜厚度减少11.65μm（P<0.001）。
与正视者相比，高度近视的尼泊尔受试者的脉络膜明显更薄。MSE和眼轴长度与SFCT呈负相关。在本研究中，年龄对SFCT没有影响。这些发现可能对解释近视患者临床和流行病学研究中的脉络膜厚度值有启示，尤其是在南亚人群中。
