Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.
State Key Laboratory of Food Science and Technology, Nanchang University, Jiangxi, China.
Crit Rev Food Sci Nutr. 2023;63(24):7016-7024. doi: 10.1080/10408398.2022.2039898. Epub 2022 Feb 20.
Food allergy is a pathological immune reaction triggered by normal innocuous dietary proteins. Soybean is widely used in many food products and has long been recognized as a source of high-quality proteins. However, soybean is listed as one of the 8 most significant food allergens. The prevalence of soybean allergy is increasing worldwide and impacts the quality of life of patients. Currently, the only strategy to manage food allergy relies on strict avoidance of the offending food. Nutritional supplementation is a new prevention strategy which is currently under evaluation. Selenium (Se), as one of the essential micronutrients for humans and animals, carries out biological effects through its incorporation into selenoproteins. The use of interventions with micronutrients, like Se, might be an interesting new approach. In this review we describe the involvement of Se in a variety of processes, including maintaining immune homeostasis, preventing free radical damage, and modulating the gut microbiome, all of which may contribute to in both the prevention and treatment of food allergy. Se interventions could be an interesting new approach for future treatment strategies to manage soybean allergy, and food allergy in general, and could help to improve the quality of life for food allergic patients.
食物过敏是一种由正常无害的膳食蛋白引发的病理性免疫反应。大豆被广泛应用于多种食品，长期以来被认为是优质蛋白质的来源。然而，大豆被列为 8 种最主要的食物过敏原之一。大豆过敏的患病率在全球范围内呈上升趋势，影响着患者的生活质量。目前，管理食物过敏的唯一策略是严格避免食用致敏食物。营养补充是一种新的预防策略，目前正在评估中。硒（Se）是人类和动物必需的微量元素之一，通过其掺入到硒蛋白中发挥生物作用。使用干预措施来补充微量元素，如硒，可能是一种有趣的新方法。在这篇综述中，我们描述了 Se 参与多种过程的情况，包括维持免疫稳态、防止自由基损伤和调节肠道微生物群，所有这些都可能有助于预防和治疗食物过敏。Se 干预可能是未来治疗策略管理大豆过敏和一般食物过敏的一种有趣的新方法，并有助于提高食物过敏患者的生活质量。
