Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, Ministry of Education, China Agricultural University, Beijing 100083, China.
Nutrients. 2022 Jul 29;14(15):3133. doi: 10.3390/nu14153133.
Selenium (Se) is an essential micronutrient that functions in the body mainly in the form of selenoproteins. The selenoprotein contains 25 members in humans that exhibit a number of functions. Selenoproteins have immunomodulatory functions and can enhance the ability of immune system to regulate in a variety of ways, which can have a preventive effect on immune-related diseases. Food allergy is a specific immune response that has been increasing in number in recent years, significantly reducing the quality of life and posing a major threat to human health. In this review, we summarize the current understanding of the role of Se and selenoproteins in regulating the immune system and how dysregulation of these processes may lead to food allergies. Thus, we can explain the mechanism by which Se and selenoproteins boost immunity to prevent food allergies.
硒（Se）是一种必需的微量元素，在体内主要以硒蛋白的形式发挥作用。硒蛋白在人体内含有 25 个成员，具有多种功能。硒蛋白具有免疫调节功能，可以通过多种方式增强免疫系统的调节能力，对免疫相关疾病具有预防作用。食物过敏是一种特定的免疫反应，近年来其发病率不断增加，显著降低了生活质量，对人类健康构成重大威胁。在这篇综述中，我们总结了目前对硒和硒蛋白调节免疫系统的作用的认识，以及这些过程的失调如何导致食物过敏。因此，我们可以解释硒和硒蛋白增强免疫力以预防食物过敏的机制。
