Gripois D, Valens M
Biol Neonate. 1986;49(4):219-23. doi: 10.1159/000242534.
The postnatal evolution of adrenal phenylethanolamine-N-methyltransferase (PNMT) activity is slightly accelerated by hypothyroidism and slowed by hyperthyroidism. In 14-day-old rats a single stimulation of the adrenals by insulin-induced hypoglycemia does not lead to any change in enzymatic activity. If the stimulation is repeated for 4 days, it leads to a net increase in adrenal PNMT activity in the control rats, while no increase occurs in hypo- or hyperthyroid animals.
甲状腺功能减退会使肾上腺苯乙醇胺 - N - 甲基转移酶(PNMT)活性的产后演变略有加速,而甲状腺功能亢进则会使其减慢。在14日龄的大鼠中,胰岛素诱导的低血糖对肾上腺进行单次刺激不会导致酶活性发生任何变化。如果连续4天重复刺激,会使对照大鼠的肾上腺PNMT活性净增加,而甲状腺功能减退或亢进的动物则不会增加。