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单侧前庭终器切除后松鼠猴的γ-氨基丁酸失衡

GABA imbalance in squirrel monkey after unilateral vestibular end-organ ablation.

作者信息

Thompson G C, Igarashi M, Cortez A M

出版信息

Brain Res. 1986 Apr 2;370(1):182-5. doi: 10.1016/0006-8993(86)91121-2.

DOI:10.1016/0006-8993(86)91121-2
PMID:3518859
Abstract

Using an antibody against GABA conjugated to bovine serum albumin, GABA-like immunoreactivity was measured in vestibular nuclei and adjacent structures in normal and unilaterally vestibular-deafferentiated squirrel monkeys. Three and 6 days after end-organ ablation, GABA levels increased in lateral vestibular nucleus (LVN) on the side ipsilateral to the lesion, while GABA decreased in LVN on the side contralateral to the lesion. GABA levels in ventral cochlear nucleus or inferior cerebellar peduncle did not differ from normal in either case.

摘要

使用与牛血清白蛋白偶联的抗γ-氨基丁酸(GABA)抗体,在正常和单侧前庭去传入松鼠猴的前庭核及相邻结构中测量GABA样免疫反应性。终器切除后3天和6天,病变同侧的外侧前庭核(LVN)中GABA水平升高,而病变对侧的LVN中GABA水平降低。在这两种情况下,腹侧耳蜗核或小脑下脚中的GABA水平与正常情况无差异。

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