Guangdong Xianqiang Pharmaceutical Co., Ltd, Guangzhou, P.R. China.
Guangdong Zhongsheng Pharmaceutical Co., Ltd, Dongguan, Guangdong, P.R. China.
Curr Top Med Chem. 2022;22(12):1009-1019. doi: 10.2174/1568026622666220221110506.
Flavonoids, a wide variety of phenolic secondary metabolites, are found in almost all plant families in the leaves, stems, roots, flowers, and seeds. Flavonoids could exert antibacterial activity via damaging the cytoplasmic membrane, inhibiting energy metabolism, and inhibiting the synthesis of nucleic acids, so flavonoids are considered constitutive antibacterial substances. This review aims to outline the recent advances of natural-derived flavonoids, including flavonoid glycosides with antibacterial potential to provide novel antibacterial lead hits/candidates, covering articles published between January 2016 and July 2021.
类黄酮是一种广泛存在于几乎所有植物科的酚类次生代谢产物，存在于植物的叶、茎、根、花和种子中。类黄酮可以通过破坏细胞质膜、抑制能量代谢和抑制核酸合成来发挥抗菌活性，因此类黄酮被认为是固有抗菌物质。本综述旨在概述天然来源的类黄酮的最新进展，包括具有抗菌潜力的类黄酮糖苷，为提供新的抗菌先导物/候选物，涵盖了 2016 年 1 月至 2021 年 7 月期间发表的文章。
