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保留 Retzius 技术独立预测机器人辅助根治性前列腺切除术后早期尿控恢复。

Retzius-sparing technique independently predicts early recovery of urinary continence after robot-assisted radical prostatectomy.

机构信息

Department of Urology, Ipswich Hospital, Ipswich, UK.

Department of Medicine, Queen Elizabeth Hospital, Woolwich, UK.

出版信息

J Robot Surg. 2022 Dec;16(6):1419-1426. doi: 10.1007/s11701-022-01383-z. Epub 2022 Feb 22.

Abstract

Robot-assisted radical prostatectomy (RARP) is the conventional surgical treatment option for localised prostate cancer. We investigated factors which may be associated with recovery of early urinary continence (EUC), including the use of the Retzius-sparing technique (RS-RARP). From March 2018 to December 2018, 501 consecutive patients underwent RARP at our high-volume institution. Four hundred and thirty-one patients had complete follow-up data and were included in our analyses. EUC was defined as zero pad use and social urinary continence (SUC) was defined as ≤ 1 pad/24-h period at 3 months following surgery. Patient demographics and clinical factors such as age, body mass index (BMI), neurovascular bundle (NVB) sparing, RS-RARP operative technique and operating surgeon (consultant, trainee) were recorded. Median age was 64.0 years (IQR 57.0-69.0 years) with a median BMI of 27.0 (IQR 25.0-29.9). RS-RARP accounted for 59 of the 431 (13.7%) patients. 196 (45.5%), 142 (32.9%) and 86 (20.0%) received a bilateral, unilateral and nil NVB sparing, respectively. EUC was achieved by 241 patients (55.9%) and SUC was achieved in 339 (78.7%) patients. Multivariable logistic regression analysis suggests younger age (HR 1.04, 95% CI 1.01-1.07, p = 0.014) and RS-RARP technique (HR 2.19, 95% CI 1.15-4.16, p = 0.017) were independently associated with EUC at 3 months even after adjusting for BMI, external membranous urethral length and NVB sparing. Our results suggest that RS-RARP technique is independently predictive of EUC even after accounting for confounding factors. These findings should be further validated in a prospective or randomised trial.

摘要

机器人辅助根治性前列腺切除术(RARP)是局部前列腺癌的常规手术治疗选择。我们研究了可能与早期尿控恢复相关的因素,包括使用保留耻骨后间隙技术(RS-RARP)。 2018 年 3 月至 2018 年 12 月,我们的高容量机构对 501 例连续患者进行了 RARP。431 例患者有完整的随访数据,并纳入我们的分析。早期尿控定义为零垫使用,社交尿控定义为术后 3 个月时≤1 片/24 小时。记录了患者人口统计学和临床因素,如年龄、体重指数(BMI)、神经血管束(NVB)保留、RS-RARP 手术技术和手术医生(顾问、受训者)。中位年龄为 64.0 岁(IQR 57.0-69.0 岁),中位 BMI 为 27.0(IQR 25.0-29.9)。RS-RARP 占 431 例患者中的 59 例(13.7%)。分别有 196 例(45.5%)、142 例(32.9%)和 86 例(20.0%)接受了双侧、单侧和无 NVB 保留。241 例(55.9%)患者实现早期尿控,339 例(78.7%)患者实现社交尿控。多变量逻辑回归分析表明,年龄较小(HR 1.04,95%CI 1.01-1.07,p=0.014)和 RS-RARP 技术(HR 2.19,95%CI 1.15-4.16,p=0.017)与术后 3 个月的早期尿控独立相关,即使在调整 BMI、外部膜状尿道长度和 NVB 保留后也是如此。我们的结果表明,即使在考虑混杂因素后,RS-RARP 技术仍然与早期尿控独立相关。这些发现应在前瞻性或随机试验中进一步验证。

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