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影响类风湿关节炎患者对成本和治疗效果满意度的因素:来自多中心观察性队列研究 FRANK 注册表的结果。

Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry.

机构信息

Department of Orthopaedic Surgery, Kyushu University Graduate School of Medical Sciences, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Kondo Clinic of Rheumatology and Orthopaedic Surgery, Fukuoka, Japan.

出版信息

Arthritis Res Ther. 2022 Feb 22;24(1):53. doi: 10.1186/s13075-022-02746-5.

DOI:10.1186/s13075-022-02746-5
PMID:35193646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8862466/
Abstract

BACKGROUND

To further improve rheumatoid arthritis (RA) treatment, it is necessary to understand each RA patient's satisfaction and to identify the factors affecting their satisfaction. Despite the rise in medical costs for RA, little is known about the factors that influence patient satisfaction with the cost of treatment in RA patients.

METHODS

This is a multicenter observational study of Japanese RA patients from the FRANK Registry with data analyzed from March 2017 to August 2020. We collected data on demographic characteristics, clinical data, quality of life which was evaluated using the EuroQol 5-dimensional questionnaire (EQ5D), and patient satisfaction. The four categories of patient satisfaction were evaluated individually (i.e., cost, treatment efficacy, activities of daily living [ADL], and global treatment satisfaction). We analyzed the factors that affected each patient's satisfaction, such as age, sex, EQ5D, disease duration, disease activity, and treatment.

RESULTS

This study included 2235 RA outpatients (406 males, 1829 females). In RA patients, "very satisfied" and "satisfied" were given for nearly half of each satisfaction aspect (cost 49%; efficacy 72%; ADL 58%; global treatment 66%) at the time of the initial registration. To investigate the factors influencing each satisfaction, multivariate analysis has revealed that the use of b/tsDMARDs increased satisfaction of treatment effect (odds ratio [OR] 0.66) and ADL (OR 0.78) but decreased cost satisfaction (OR 2.21). Age (50-64 years; OR 0.91; 65-74 years, 0.55: ≥ 75 years, 0.35), female (OR 0.81), and history of musculoskeletal surgery (OR 0.60) all increased cost satisfaction. Patients with lower disease activity and higher EQ5D scores had higher levels of satisfaction in all areas.

CONCLUSIONS

In this study, patient satisfaction in terms of cost, treatment effect, ADL, and overall treatment was generally higher, but some patients were dissatisfied. The cost of satisfaction increased with age and a history of musculoskeletal surgery, while it decreased with a lower EQ5D score and the use of b/tsDMARDs.

摘要

背景

为了进一步改善类风湿关节炎(RA)的治疗效果,有必要了解每位 RA 患者的满意度,并确定影响其满意度的因素。尽管 RA 的医疗费用有所增加,但对于影响 RA 患者治疗费用满意度的因素知之甚少。

方法

这是一项来自 FRANK 登记处的日本 RA 患者的多中心观察性研究,数据分析时间为 2017 年 3 月至 2020 年 8 月。我们收集了人口统计学特征、临床数据、生活质量(使用欧洲五维健康量表问卷[EQ5D]进行评估)和患者满意度的数据。我们分别评估了患者满意度的四个类别(即成本、治疗效果、日常生活活动[ADL]和整体治疗满意度)。我们分析了影响每位患者满意度的因素,例如年龄、性别、EQ5D、疾病持续时间、疾病活动度和治疗方法。

结果

这项研究包括 2235 名 RA 门诊患者(406 名男性,1829 名女性)。在 RA 患者中,在初始登记时,几乎每个满意度方面(成本 49%;疗效 72%;ADL 58%;整体治疗 66%)都给予了“非常满意”和“满意”的评价。为了研究影响每个满意度的因素,多变量分析显示 b/tsDMARDs 的使用增加了治疗效果的满意度(比值比[OR]0.66)和 ADL(OR0.78),但降低了成本满意度(OR2.21)。年龄(50-64 岁;OR0.91;65-74 岁,0.55:≥75 岁,0.35)、女性(OR0.81)和肌肉骨骼手术史(OR0.60)均增加了成本满意度。疾病活动度较低和 EQ5D 评分较高的患者在所有领域的满意度均较高。

结论

在这项研究中,患者在成本、治疗效果、ADL 和整体治疗方面的满意度普遍较高,但也有一些患者不满意。成本满意度随年龄和肌肉骨骼手术史的增加而增加,随 EQ5D 评分和 b/tsDMARDs 的使用而降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/bcdf528b0a9a/13075_2022_2746_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/f6032973eb04/13075_2022_2746_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/e92fe41dd372/13075_2022_2746_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/bcdf528b0a9a/13075_2022_2746_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/f6032973eb04/13075_2022_2746_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/e92fe41dd372/13075_2022_2746_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/8862466/bcdf528b0a9a/13075_2022_2746_Fig3_HTML.jpg

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