State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, China.
Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, China.
Nat Commun. 2022 Feb 22;13(1):999. doi: 10.1038/s41467-022-28645-6.
Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. Here we identify IFN-υ from the genomic sequences of vertebrates. The members of class II cytokine receptors, IFN-υR1 and IL-10R2, are identified as the receptor complex of IFN-υ, and are associated with IFN-υ stimulated gene expression and antiviral activity in zebrafish (Danio rerio) and African clawed frog (Xenopus laevis). IFN-υ and IFN-υR1 are separately located at unique and highly conserved loci, being distinct from all other three-type IFNs. IFN-υ and IFN-υR1 are phylogenetically clustered with class II cytokines and class II cytokine receptors, respectively. Therefore, the finding of this IFN ligand-receptor system may be considered as a type IV IFN, in addition to the currently recognized three types of IFNs in vertebrates.
干扰素 (IFNs) 是免疫系统中的关键可溶性因子，由三种类型组成 (I、II 和 III)，分别利用不同的受体复合物 IFN-αR1/IFN-αR2、IFN-γR1/IFN-γR2 和 IFN-λR1/IL-10R2。在这里，我们从脊椎动物的基因组序列中鉴定出了干扰素-υ。II 类细胞因子受体的成员 IFN-υR1 和 IL-10R2 被鉴定为 IFN-υ 的受体复合物，并与斑马鱼 (Danio rerio) 和非洲爪蟾 (Xenopus laevis) 中的 IFN-υ 刺激基因表达和抗病毒活性相关。IFN-υ 和 IFN-υR1 分别位于独特且高度保守的基因座上，与所有其他三种类型的 IFNs 不同。IFN-υ 和 IFN-υR1 在系统发育上与 II 类细胞因子和 II 类细胞因子受体聚类，分别。因此，除了脊椎动物中目前公认的三种 IFN 之外，这种 IFN 配体-受体系统的发现可以被认为是一种 IV 型 IFN。
