二氢槲皮素的生物利用度与安全性（综述）
Bioavailability and Safety of Dihydroquercetin (Review).
作者信息
Orlova S V, Tatarinov V V, Nikitina E A, Sheremeta A V, Ivlev V A, Vasil'ev V G, Paliy K V, Goryainov S V
机构信息
Peoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
A. P. Vinogradov Institute of Geochemistry, Siberian Branch, Russian Academy of Sciences, 1A Favorskogo St., P. O. Box 9, Irkutsk, 664033 Russia.
出版信息
Pharm Chem J. 2022;55(11):1133-1137. doi: 10.1007/s11094-022-02548-8. Epub 2022 Feb 11.
Abstract
Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.
摘要
二氢槲皮素（DHQ）是一种具有高抗氧化、保护毛细血管和抗炎活性的生物类黄酮。DHQ此前已用于治疗中东呼吸综合征冠状病毒（MERS-CoV）感染，目前作为新冠肺炎多用途治疗的一部分，被认为是氧化应激的潜在调节剂。DHQ具有较高的安全性，但生物利用度较低，这限制了其应用。可采用创新技术（脂质体化、晶体工程等）来提高其生物利用度。
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