兔粒细胞肽对白色念珠菌的协同活性。
Synergistic activity of rabbit granulocyte peptides against Candida albicans.
作者信息
Lehrer R I, Szklarek D, Ganz T, Selsted M E
出版信息
Infect Immun. 1986 Jun;52(3):902-4. doi: 10.1128/iai.52.3.902-904.1986.
Abstract
Rabbit granulocytes contain six antimicrobial peptides that are structurally homologous to the human neutrophil "defensins." NP-5, a rabbit defensin, lacks significant activity against Candida albicans. Nevertheless, its addition to submicromolar concentrations of rabbit NP-1, NP-2, or NP-3a potentiates their candidacidal effect. Thus, granulocyte defensins can act synergistically against potential pathogens.
摘要
兔粒细胞含有六种抗菌肽，其结构与人类中性粒细胞“防御素”同源。兔防御素NP-5对白色念珠菌缺乏显著活性。然而，将其添加到亚微摩尔浓度的兔NP-1、NP-2或NP-3a中可增强它们的杀念珠菌作用。因此，粒细胞防御素可协同作用对抗潜在病原体。
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