Gilchrist M J, Kraft J A, Hammond J G, Connelly B L, Myers M G
J Clin Microbiol. 1986 Jun;23(6):1052-5. doi: 10.1128/jcm.23.6.1052-1055.1986.
Pseudomonas mesophilica was isolated from fungal blood cultures of two bone marrow transplant recipients who consecutively occupied the same room. The isolation of P. mesophilica was temporally associated with febrile illness in these two granulocytopenic patients at 1 and 3 weeks posttransplant. A third patient, housed separately on the same bone marrow transplant unit, had nasopharyngeal colonization by this organism. Epidemiologic risk factors in common included staff, medications, and oral and perineal irrigations with tap water. Surveillance cultures detected P. mesophilica in none of 24 pharmaceutical preparations and in 10 of 40 tap water samples (100 to 600 CFU/ml) from implicated and control rooms on the same floor. Antimicrobial susceptibility testing of 14 patients and environmental isolates by agar dilution revealed similar profiles; some environmental isolates exhibited higher MICs. Because of restrictive nutritional and temperature requirements, P. mesophilica is undetected by many clinical laboratory protocols and may represent a previously undetected source of febrile illness in neutropenic patients.
嗜温假单胞菌是从两名连续入住同一病房的骨髓移植受者的真菌血培养物中分离出来的。在这两名粒细胞减少症患者移植后1周和3周时，嗜温假单胞菌的分离与发热性疾病在时间上相关。第三名患者单独住在同一骨髓移植病房，其鼻咽部被该菌定植。共同的流行病学危险因素包括工作人员、药物以及用自来水进行口腔和会阴冲洗。监测培养在24种药物制剂中均未检测到嗜温假单胞菌，在同一楼层相关病房和对照病房的40份自来水样本中有10份检测到该菌（100至600 CFU/ml）。通过琼脂稀释法对14例患者和环境分离株进行的药敏试验显示出相似的结果；一些环境分离株的最低抑菌浓度更高。由于嗜温假单胞菌对营养和温度有严格要求，许多临床实验室检测方案无法检测到它，它可能是中性粒细胞减少症患者发热性疾病的一个以前未被发现的来源。
