抗焦虑药物的药理学，特别提及氯巴占。
Pharmacology of anti-anxiety drugs with special reference to clobazam.
作者信息
Fielding S, Hoffmann I
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):7S-15S.
Abstract
1 In several studies clobazam exhibited a potency which ranges between that of chlordiazepoxide and diazepam. Its anxiolytic and anti-aggression effects are produced by doses usually ranging below those that cause disorders in motor activity. 2 This separation was demonstrable to an even greater degree with the desmethyl metabolite. The activity of the metabolite, however, was weaker than that of the original substance. 3 The advantage of clobazam compared with the 1.4 benzodiazepines lies mainly in the fact that motor activity is influenced only after very high doses, these doses being markedly above those required to induce tranquillizing and anti-agression activities. 4 Clobazam has no marked effect on the cardiovascular system, respiration of excretion.
摘要
- 在多项研究中，氯巴占的效力介于氯氮卓和地西泮之间。其抗焦虑和抗攻击作用通常由低于引起运动活动障碍的剂量产生。2. 去甲基代谢物的这种分离程度更大。然而，代谢物的活性比原物质弱。3. 氯巴占与1,4 - 苯二氮卓类药物相比的优势主要在于，只有在非常高的剂量下才会影响运动活动，这些剂量明显高于诱导镇静和抗攻击活性所需的剂量。4. 氯巴占对心血管系统、呼吸和排泄没有明显影响。
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