Marsh Henry R, Miyake Bradley A, Alamiri Nasser N, Mims Mark M
School of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla.
Department of Surgery - Division of Plastic and Reconstructive Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, Okla.
Plast Reconstr Surg Glob Open. 2022 Feb 17;10(2):e4120. doi: 10.1097/GOX.0000000000004120. eCollection 2022 Feb.
Calcinosis cutis is a common dermatological problem in patients with systemic sclerosis, dermatomyositis, and systemic lupus erythematous; however, it is rare to occur outside of these diseases. It represents a multidisciplinary problem that involves primary care physicians, dermatologists, and surgeons. The pathophysiology is defined by deposition of calcium salts in the subcutaneous tissue as hydroxyapatite, but the underlying mechanism has yet to be determined. The most common locations of lesions are the scalp, scrotum, extremities, and joints. Rarely does calcinosis cutis occur on the face. We present a unique case of idiopathic calcinosis cutis that occurred in a healthy patient with normal serum calcium and phosphate levels on the nasal dorsum, which was managed surgically. The histology of the calcinosis showed normal morphology, dominated by large deposits of calcium and normal surrounding tissues. This case represents a rare but clinically relevant presentation of idiopathic calcinosis cutis in an otherwise healthy individual.
皮肤钙化症是系统性硬化症、皮肌炎和系统性红斑狼疮患者常见的皮肤病问题；然而，在这些疾病之外发生的情况很少见。它是一个涉及初级保健医生、皮肤科医生和外科医生的多学科问题。其病理生理学表现为皮下组织中钙盐以羟基磷灰石形式沉积，但潜在机制尚未确定。病变最常见的部位是头皮、阴囊、四肢和关节。皮肤钙化症很少发生在面部。我们报告了一例特发性皮肤钙化症的独特病例，该病例发生在一名血清钙和磷水平正常的健康患者的鼻背部，通过手术进行了处理。钙化症的组织学显示形态正常，主要为大量钙沉积和正常的周围组织。该病例代表了特发性皮肤钙化症在健康个体中罕见但具有临床相关性的表现。
