NCAPG is a prognostic biomarker of immune infiltration in non-small-cell lung cancer.

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths. The protein plays a significant role in tumor development. We set up a tissue microarray (containing 140 NSCLC and ten normal lung tissues) and performed immunohistochemistry to assess expression in the tissues of 140 patients. The prognostic value of in NSCLC was assessed using the univariate and multivariate Cox proportional hazards regression models and Kaplan-Meier plots. We analyzed the association between and immune infiltration in NSCLC. Multifactorial analysis and Kaplan-Meier plots revealed that upregulation of expression was an independent factor in the prognosis of NSCLC. Data from CIBERSORT showed a negative correlation between and the expression of memory CD4 T cells, CD8 T cells, dendritic cells, macrophages, mast cells and natural killer cells (p < 0.001). Gene set enrichment analysis revealed that cell cycle, adhesion and proliferation were significantly enriched in samples with a high expression. is a novel biomarker of prognosis and is associated with immune cell infiltration in the tumor microenvironment. Thus it may be a potential target in NSCLC treatment.