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LncRNA-AL035458.2/hsa-miR-181a-5p轴介导的NCAPG2高表达与肿瘤免疫浸润及非小细胞肺癌进展相关。

LncRNA-AL035458.2/hsa-miR-181a-5p Axis-Mediated High Expression of NCAPG2 Correlates With Tumor Immune Infiltration and Non-Small Cell Lung Cancer Progression.

作者信息

Chen Xi, Guo Jishu, Ren Wenjun, Zhou Fan, Niu Xiaoqun, Jiang Xiulin

机构信息

Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.

Institute for Ecological Research and Pollution Control of Plateau Lakes, School of Ecology and Environmental Science, Yunnan University, Kunming, China.

出版信息

Front Oncol. 2022 May 19;12:910437. doi: 10.3389/fonc.2022.910437. eCollection 2022.

DOI:10.3389/fonc.2022.910437
PMID:35664767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9160743/
Abstract

Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it is the leading cause of cancer-related deaths worldwide. NCAPG2 (non-SMC condensin II complex subunit G2) has been shown to be upregulated in various human cancers. Nevertheless, the underlying biological function and potential mechanisms of NCAPG2 driving the progression of LUAD remain unclear. In this study, we investigated the role of NCAPG2 in LUAD and found that the expression of NCAPG2 in LUAD tissues was significantly higher than that of NCAPG2 expression in adjacent normal tissues. Kaplan-Meier survival analysis showed that patients with higher NCAPG2 expression correlated with unfavorable clinical outcomes. Receiver operating characteristic (ROC) curve analysis showed that the AUC value of NCAPG2 was 0.914. Correlation analysis showed that NCAPG2 expression was associated with immune infiltration in LUAD. Finally, we found that AL139385.1 was upregulated in LUAD cancer tissues and cell lines. Knockdown of NCAPG2 inhibited cell proliferation, cell migration, and cell invasion of LUAD . More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD. In conclusion, our data demonstrated that ncRNA-mediated high expression of NCAPG2 was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for LUAD.

摘要

肺腺癌（LUAD）是最常见的组织学类型肺癌，也是全球癌症相关死亡的主要原因。已有研究表明，非SMC凝聚素II复合体亚基G2（NCAPG2）在多种人类癌症中上调。然而，NCAPG2驱动LUAD进展的潜在生物学功能和机制仍不清楚。在本研究中，我们调查了NCAPG2在LUAD中的作用，发现LUAD组织中NCAPG2的表达明显高于相邻正常组织中的表达。Kaplan-Meier生存分析表明，NCAPG2表达较高的患者临床预后较差。受试者工作特征（ROC）曲线分析表明，NCAPG2的AUC值为0.914。相关性分析表明，NCAPG2表达与LUAD中的免疫浸润相关。最后，我们发现AL139385.1在LUAD癌组织和细胞系中上调。敲低NCAPG2可抑制LUAD的细胞增殖、细胞迁移和细胞侵袭。更重要的是，我们确定AL035458.2/hsa-miR-181a-5p轴是LUAD中NCAPG2最可能的上游非编码RNA相关途径。总之，我们的数据表明，非编码RNA介导的NCAPG2高表达与LUAD的进展和免疫浸润相关，并且可作为LUAD的预后生物标志物。

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