Feng Huidong, Chen Ning, Li Huanhuan, Zheng Zhiwu, Li Hua, Quan Haiyan, Jin Xing, Jiang Ping, Wu Qiong, Yang Xuejiao
Department of Infectious Diseases, Yanbian University Hospital, Yanji, Jilin Province, PR China.
Central Laboratory, Yanbian University Hospital, Yanji, Jilin Province, PR China.
Heliyon. 2023 Jul 13;9(7):e18051. doi: 10.1016/j.heliyon.2023.e18051. eCollection 2023 Jul.
NCAPG2 has been reported to be associated with tumorigenesis in various types of cancer. However, data on the pathological mechanisms of NCAPG2 in pan-cancers remain lacking. Therefore, the study aimed to comprehensively elucidate the immune characteristics and prognostic of NCAPG2 in tumor microenvironments (TMEs). NCAPG2 was overexpressed in many tumor types, and this overexpression is related to poor clinical stages and prognosis. Furthermore, elevated NCAPG2 expression was strongly associated with TMEs. Moreover, gene set enrichment analysis was performed to investigate the pathways associated with NCAPG2, revealing its involvement in several immune-related pathways. Finally, we predicted the immunotherapeutic value and sensitivity to drugs based on NCAPG2 expression. Our study revealed that NCAPG2 could be utilized as an immune-related biomarker for both diagnosing and predicting the prognosis of multiple cancer types. Therefore, our findings suggest that targeting NCAPG2 in TMEs could be a promising therapeutic strategy.
据报道，NCAPG2与多种类型癌症的肿瘤发生有关。然而，关于NCAPG2在泛癌中的病理机制的数据仍然缺乏。因此，本研究旨在全面阐明NCAPG2在肿瘤微环境（TME）中的免疫特征和预后情况。NCAPG2在许多肿瘤类型中均有过表达，且这种过表达与临床分期差和预后不良有关。此外，NCAPG2表达升高与TME密切相关。此外，进行了基因集富集分析以研究与NCAPG2相关的通路，结果显示它参与了多个免疫相关通路。最后，我们基于NCAPG2表达预测了免疫治疗价值和对药物的敏感性。我们的研究表明，NCAPG2可作为一种免疫相关生物标志物用于多种癌症类型的诊断和预后预测。因此，我们的研究结果表明，在TME中靶向NCAPG2可能是一种有前景的治疗策略。
