Attili Suresh Venkata Satya, Singh V P, Rai Madhukar, Varma Datla Vivekananda, Gulati A K, Sundar Shyam
Turk J Haematol. 2008 Mar 5;25(1):13-9.
To study the spectrum of hematological manifestations and evaluate the relationship between various hematological manifestations and CD4 cell counts in a hospital-based cohort of HIV-infected adults in and around Varanasi, North India.
MATERIALS-METHODS: The clinical and hematological profiles of the patients attending the Infectious Disease Clinic, Varanasi, India were recorded. The relationship between CD4 counts and various hematological manifestations was analyzed.
A total of 470 HIV-infected individuals were followed for 830 person years of observation (PYO). Rate of hematological episodes was 1047 episodes per 1000 PYO. CD4 counts were significantly lower in individuals with severe anemia and neutropenia compared to those without. However, no relation could be established between thrombocytopenia and CD4 counts. In the above- mentioned population, CD4 levels were significantly lower in those with anemia/neutropenia harboring any particular disease compared to those who had the same disease without anemia/ neutropenia.
There is a strong negative association between CD4 counts and the severity of anemia and neutropenia in this population. They can be considered as good clinical indicators to predict and access the underlying immune status. Though fall in the CD4 levels during neutropenia is observed, it is difficult to comment since the estimations of CD4 rely on the total leukocyte counts. However, the relation between anemia and disease progression is straight forward and quite useful for the treating physician.
在印度北部瓦拉纳西及其周边地区一家医院的成年HIV感染者队列中，研究血液学表现谱，并评估各种血液学表现与CD4细胞计数之间的关系。
记录印度瓦拉纳西传染病诊所患者的临床和血液学资料。分析CD4计数与各种血液学表现之间的关系。
共对470名HIV感染者进行了830人年的观察（PYO）。血液学事件发生率为每1000人年1047次。与无严重贫血和中性粒细胞减少症的个体相比，有严重贫血和中性粒细胞减少症的个体CD4计数显著更低。然而，血小板减少症与CD4计数之间未发现相关性。在上述人群中，患有任何特定疾病且伴有贫血/中性粒细胞减少症的个体的CD4水平，显著低于患有相同疾病但无贫血/中性粒细胞减少症的个体。
在该人群中，CD4计数与贫血和中性粒细胞减少症的严重程度之间存在强烈的负相关。它们可被视为预测和评估潜在免疫状态的良好临床指标。尽管在中性粒细胞减少症期间观察到CD4水平下降，但由于CD4的估计依赖于白细胞总数，因此难以对此进行评论。然而，贫血与疾病进展之间的关系是直接的，对治疗医生非常有用。
