Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100190, China.
Biosensors (Basel). 2022 Feb 6;12(2):100. doi: 10.3390/bios12020100.
As an essential substance for cell life activities, ions play an important role in controlling cell osmotic pressure balance, intracellular acid-base balance, signal transmission, biocatalysis and so on. The imbalance of ion homeostasis in cells will seriously affect the activities of cells, cause irreversible damage to cells or induce cell death. Therefore, artificially interfering with the ion homeostasis in tumor cells has become a new means to inhibit the proliferation of tumor cells. This treatment is called ion interference therapy (IIT). Although some molecular carriers of ions have been developed for intracellular ion delivery, inorganic nanoparticles are widely used in ion interference therapy because of their higher ion delivery ability and higher biocompatibility compared with molecular carriers. This article reviewed the recent development of IIT based on inorganic nanoparticles and summarized the advantages and disadvantages of this treatment and the challenges of future development, hoping to provide a reference for future research.
作为细胞生命活动的必需物质，离子在控制细胞渗透压平衡、细胞内酸碱平衡、信号转导、生物催化等方面发挥着重要作用。细胞内离子动态平衡的失衡会严重影响细胞的活动，导致细胞不可逆损伤或诱导细胞死亡。因此，人为干预肿瘤细胞内的离子动态平衡成为抑制肿瘤细胞增殖的一种新手段。这种治疗方法被称为离子干扰治疗（IIT）。尽管已经开发出一些用于细胞内离子输送的离子分子载体，但与分子载体相比，无机纳米粒子由于具有更高的离子输送能力和更好的生物相容性，因此在离子干扰治疗中得到了广泛应用。本文综述了基于无机纳米粒子的 IIT 的最新进展，并总结了这种治疗方法的优缺点及未来发展所面临的挑战，以期为未来的研究提供参考。
