Department of Pharmacoepidemiology, Kyoto University Graduate School of Medicine and Public Health, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Department of Digital Health and Epidemiology, Kyoto University Graduate School of Medicine and Public Health, Kyoto, Japan.
Child Psychiatry Hum Dev. 2023 Oct;54(5):1250-1257. doi: 10.1007/s10578-022-01330-x. Epub 2022 Feb 24.
Little is known about antipsychotic prescription patterns among children and adolescents in Japan, particularly in outpatient settings. We investigated the prevalence and trends of antipsychotic prescription for outpatients aged ≤ 17 years receiving a first antipsychotic prescription from 2006 to 2012 based on a large-scale dispensation dataset. Measurements included age, sex, department of diagnosis and treatment, type of prescription (monotherapy or polytherapy), antipsychotic dosage, and concomitant psychotropic drugs. Of the 10,511 patients, 65.1% were aged 13-17 years, and 52.9% were males. Second-generation antipsychotic monotherapy prescriptions increased from 53.8% in 2006 to 78.3% in 2012. Risperidone was the most frequently prescribed antipsychotic, followed by aripiprazole and olanzapine. Approximately 25.0% of patients were prescribed an initial dose less than recommended. Second-generation antipsychotic monotherapy is currently the most frequent prescription pattern among outpatients aged ≤ 17 years receiving an initial antipsychotic prescription.
目前，在日本，人们对于儿童和青少年的精神科药物处方模式知之甚少，尤其是在门诊环境下。本研究基于一项大规模的处方数据集，旨在调查 2006 年至 2012 年期间首次接受精神科药物处方的年龄≤17 岁的门诊患者中抗精神病药物处方的流行率和趋势。测量指标包括年龄、性别、诊断和治疗科室、处方类型（单药治疗或联合用药）、抗精神病药物剂量和同时使用的精神药物。在 10511 名患者中，65.1%的年龄在 13-17 岁之间，52.9%为男性。第二代抗精神病药单药治疗处方从 2006 年的 53.8%增加到 2012 年的 78.3%。利培酮是最常开的抗精神病药物，其次是阿立哌唑和奥氮平。约 25.0%的患者初始剂量低于推荐剂量。对于首次接受抗精神病药物处方的年龄≤17 岁的门诊患者，目前第二代抗精神病药单药治疗是最常见的处方模式。
