Lübke Luisa, Zhang Gaoqun, Strähle Uwe, Rastegar Sepand
Institute of Biological and Chemical Systems-Biological Information Processing (IBCS-BIP), Karlsruhe Institute of Technology (KIT), Postfach 3640, 76021 Karlsruhe, Germany.
Centre of Organismal Studies, University Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.
Brain Sci. 2022 Feb 18;12(2):284. doi: 10.3390/brainsci12020284.
In contrast to mammals, adult zebrafish display an extraordinary capacity to heal injuries and repair damage in the central nervous system. Pivotal for the regenerative capacity of the zebrafish brain at adult stages is the precise control of neural stem cell (NSC) behavior and the maintenance of the stem cell pool. The gene , a member of a small family of heparin binding growth factors, was previously shown to be involved in regeneration in the zebrafish retina, heart, and fin. Here, we investigated the expression pattern of the gene and its paralogue in the zebrafish adult telencephalon under constitutive and regenerative conditions. Our findings show that only expression is specifically restricted to the telencephalic ventricle, a stem cell niche of the zebrafish telencephalon. In this brain region, is particularly expressed in the quiescent stem cells. Interestingly, after brain injury, expression remains restricted to the resting stem cell, which might suggest a role of in regulating stem cell quiescence.
与哺乳动物不同，成年斑马鱼在中枢神经系统中表现出非凡的损伤愈合和损伤修复能力。成年阶段斑马鱼大脑再生能力的关键在于神经干细胞（NSC）行为的精确控制和干细胞池的维持。该基因是肝素结合生长因子小家族的成员之一，先前已被证明参与斑马鱼视网膜、心脏和鳍的再生。在这里，我们研究了该基因及其旁系同源基因在组成型和再生条件下斑马鱼成体端脑中的表达模式。我们的研究结果表明，只有该基因的表达特异性地局限于端脑室，即斑马鱼端脑的一个干细胞龛。在这个脑区，该基因在静止干细胞中尤其表达。有趣的是，脑损伤后，该基因的表达仍局限于静止干细胞，这可能表明该基因在调节干细胞静止方面发挥作用。
