Lee Keng Siang, Clennell Benjamin, Steward Tom G J, Gialeli Andriana, Cordero-Llana Oscar, Whitcomb Daniel J
Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UK.
Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK.
Brain Sci. 2022 Feb 19;12(2):289. doi: 10.3390/brainsci12020289.
Non-invasive focused ultrasound stimulation (FUS) is a non-ionising neuromodulatory technique that employs acoustic energy to acutely and reversibly modulate brain activity of deep-brain structures. It is currently being investigated as a potential novel treatment for Parkinson's disease (PD). This scoping review was carried out to map available evidence pertaining to the provision of FUS as a PD neuromodulatory tool. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews, a search was applied to Ovid MEDLINE, Embase, Web of Science and Cochrane Central Register of Controlled Trials on 13 January 2022, with no limits applied. In total, 11 studies were included: 8 were from China and 1 each from Belgium, South Korea and Taiwan. All 11 studies were preclinical (6 , 2 , 2 mix of and and 1 ). The preclinical evidence indicates that FUS is safe and has beneficial neuromodulatory effects on motor behaviour in PD. FUS appears to have a therapeutic role in influencing the disease processes of PD, and therefore holds great promise as an attractive and powerful neuromodulatory tool for PD. Though these initial studies are encouraging, further study to understand the underlying cellular and molecular mechanisms is required before FUS can be routinely used in PD.
无创聚焦超声刺激（FUS）是一种非电离神经调节技术，它利用声能来急性且可逆地调节深部脑结构的脑活动。目前，它正作为帕金森病（PD）的一种潜在新型治疗方法进行研究。开展这项范围综述是为了梳理与提供FUS作为PD神经调节工具相关的现有证据。根据《系统综述和Meta分析扩展版的范围综述首选报告项目》，于2022年1月13日对Ovid MEDLINE、Embase、科学网和Cochrane对照试验中央注册库进行了检索，未设限制。总共纳入了11项研究：8项来自中国，1项来自比利时、韩国和台湾地区各1项。所有11项研究均为临床前研究（6项 、2项 以及2项 与 的混合研究，还有1项 ）。临床前证据表明，FUS是安全的，并且对PD的运动行为具有有益的神经调节作用。FUS似乎在影响PD的疾病进程方面具有治疗作用，因此作为一种有吸引力且强大的PD神经调节工具具有很大的前景。尽管这些初步研究令人鼓舞，但在FUS能够常规用于PD之前，还需要进一步研究以了解其潜在的细胞和分子机制。
