Faheem Muhammad Shaheer Bin, Haroon-Ul-Rasheed Muhammad, Aftab Rohma, Faheem Qasra, Feroze Faheem, Ain Hafiza Qurat Ul, Samadi Sumaya
Department of Internal Medicine Karachi Institute of Medical Sciences, KIMS Karachi Pakistan.
CMH Multan Institute of Medical Sciences Multan Pakistan.
Health Sci Rep. 2025 Aug 27;8(9):e71197. doi: 10.1002/hsr2.71197. eCollection 2025 Sep.
Parkinson's disease (PD) is a progressive neurological condition that consists of both motor and non-motor symptoms that considerably deteriorate the quality of life. Pharmacological treatments, primarily levodopa, have been used to manage PD. However, side effects such as dyskinesias and motor fluctuations frequently limit their long-term effectiveness. In recent decades, breakthroughs and innovations in neurosurgical treatments have transformed the entire treatment landscape.
This narrative review looks at clinical research focused on neurosurgical, gene therapy, and other modern methods for treating PD. Forty-seven studies were included in the search from PubMed, while three others were taken from other databases.
Deep brain stimulation (DBS) is the most established neurosurgical technique, and has strong evidence that it can improve motor symptoms. Focused ultrasound (FUS) provides a noninvasive option, but the majority of studies related to it still lack long-term data. Gene therapy strategies like AAV2-hAADC and ProSavin have shown early-phase safety and efficacy, but are still in early clinical stages. Newer imaging techniques and robotic surgery can play a critical role PD-related surgery, in the future.
The range of PD treatment options is growing because of the newer neurosurgical and gene therapy approaches. The current results are promising, but larger-scale, controlled trials are required to show long-term safety and efficacy.
帕金森病（PD）是一种进行性神经疾病，兼具运动和非运动症状，会严重降低生活质量。药物治疗，主要是左旋多巴，一直用于治疗帕金森病。然而，诸如运动障碍和运动波动等副作用常常限制其长期疗效。近几十年来，神经外科治疗的突破与创新改变了整个治疗格局。
本叙述性综述着眼于聚焦神经外科、基因治疗及其他治疗帕金森病的现代方法的临床研究。从PubMed检索到47项研究，另外3项研究来自其他数据库。
脑深部电刺激（DBS）是最成熟的神经外科技术，有充分证据表明其可改善运动症状。聚焦超声（FUS）提供了一种非侵入性选择，但与之相关的大多数研究仍缺乏长期数据。像AAV2-hAADC和ProSavin这样的基因治疗策略已显示出早期安全性和有效性，但仍处于临床早期阶段。更新的成像技术和机器人手术未来可能在帕金森病相关手术中发挥关键作用。
由于更新的神经外科和基因治疗方法，帕金森病的治疗选择范围正在扩大。目前的结果很有前景，但需要大规模的对照试验来证明长期安全性和有效性。
