Ficial Benjamim, Corsini Iuri, Clemente Maria, Cappelleri Alessia, Remaschi Giulia, Quer Laura, Urbani Giulia, Sandrini Camilla, Biban Paolo, Dani Carlo, Benfari Giovanni
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, Italy.
Division of Neonatology, Careggi University Hospital of Florence, 50134 Florence, Italy.
Diagnostics (Basel). 2022 Jan 29;12(2):350. doi: 10.3390/diagnostics12020350.
Left atrial strain (LAS) is the most promising technique for assessment of diastolic dysfunction but few data are available in neonates. Our aim was to assess feasibility and reproducibility, and to provide reference ranges of LAS in healthy neonates in the first 48 h of life. We performed one echocardiography in 30 neonates to assess feasibility and develop a standard protocol for image acquisition and analysis. LAS reservoir (LASr), conduit (LAScd) and contraction (LASct) were measured. We performed echocardiography at 24 and 48 h of life in an unrelated cohort of 90 neonates. Median (range) gestational age and weight of the first cohort were 34.4 (26.4-40.2) weeks and 2075 (660-3680) g. LAS feasibility was 96.7%. Mean (SD) gestational age and weight of the second cohort were 34.2 (3.8) weeks and 2162 (833) g. Mean (SD) LASr significantly increased from 24 to 48 h: 32.9 (3.2) to 36.8 (4.6). Mean (SD) LAScd and LASct were stable: -20.6 (8.0) and -20.8 (9.9), -11.6 (4.9) and -13.5 (6.4). Intra and interobserver intraclass correlation coefficient for LASr, LAScd and LASct were 0.992, 0.993, 0.986 and 0.936, 0.938 and 0.871, respectively. We showed high feasibility and reproducibility of LAS in neonates and provided reference ranges.
左心房应变（LAS）是评估舒张功能障碍最有前景的技术，但关于新生儿的相关数据较少。我们的目的是评估LAS在健康新生儿出生后48小时内的可行性和可重复性，并提供其参考范围。我们对30例新生儿进行了一次超声心动图检查，以评估可行性并制定图像采集和分析的标准方案。测量了LAS储备期（LASr）、管道期（LAScd）和收缩期（LASct）。我们在90例不相关的新生儿队列中，于出生后24小时和48小时进行了超声心动图检查。第一组队列的中位（范围）胎龄和体重分别为34.4（26.4 - 40.2）周和2075（660 - 3680）克。LAS的可行性为96.7%。第二组队列的平均（标准差）胎龄和体重分别为34.2（3.8）周和2162（833）克。平均（标准差）LASr从24小时到48小时显著增加：从32.9（3.2）增至36.8（4.6）。平均（标准差）LAScd和LASct保持稳定：分别为 -20.6（8.0）和 -20.8（9.9）， -11.6（4.9）和 -13.5（6.4）。LASr、LAScd和LASct的观察者内和观察者间组内相关系数分别为0.992、0.993、0.986和0.936、0.938、0.871。我们证明了LAS在新生儿中的高可行性和可重复性，并提供了参考范围。
