乳糖阻遏蛋白阻断RNA聚合酶转录并终止转录。
lac Repressor blocks transcribing RNA polymerase and terminates transcription.
作者信息
Deuschle U, Gentz R, Bujard H
出版信息
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4134-7. doi: 10.1073/pnas.83.12.4134.
Abstract
Operator sequences are essential elements in many negatively controlled operons. By binding repressors, they prevent the formation of active complexes between RNA polymerase and promoters. Here we show that the Escherichia coli lac operator-repressor complex also efficiently interrupts ongoing transcription. This observation suggests a mechanism of action for operators located distal to promoter sequences.
摘要
操纵序列是许多负调控操纵子中的关键元件。通过结合阻遏物，它们可阻止RNA聚合酶与启动子之间形成活性复合物。我们在此表明，大肠杆菌乳糖操纵子-阻遏物复合物还能有效中断正在进行的转录。这一观察结果提示了位于启动子序列远端的操纵子的一种作用机制。
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