Parasite-Host Biology, National Institute of Malaria Research, Dwarka, New Delhi 110077, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Int J Environ Res Public Health. 2022 Feb 19;19(4):2395. doi: 10.3390/ijerph19042395.
Malaria is a severe life-threatening disease caused by the bites of parasite-infected female mosquitoes. It remains a significant problem for the most vulnerable children and women. Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. MiRNAs are the class of small non-coding RNAs consisting of 18-23 nucleotides in length that are evolutionarily conserved and regulate gene expression at a post-transcriptional level and play a significant role in various molecular mechanisms such as cell survival, cell proliferation, and differentiation. MiRNAs can help detect malaria infection as the malaria parasite could alter the miRNA expression of the host. These alterations can be diagnosed by the molecular diagnostic tool that can indicate disease. We summarize the current understanding of miRNA during malaria infection. miRNAs can also be used as biomarkers, and initial research has unearthed their potential in diagnosing and managing various diseases such as malaria.
疟疾是一种由寄生虫感染的雌性蚊子叮咬引起的严重危及生命的疾病。它仍然是最脆弱的儿童和妇女面临的重大问题。最近的研究有助于确定 microRNAs（miRNAs）与许多其他疾病之间的关系。miRNAs 是一类小的非编码 RNA，由 18-23 个核苷酸组成，在进化上是保守的，在转录后水平上调节基因表达，在细胞存活、细胞增殖和分化等各种分子机制中发挥重要作用。miRNAs 可以帮助检测疟疾感染，因为疟原虫可以改变宿主的 miRNA 表达。这些改变可以通过分子诊断工具来诊断，该工具可以指示疾病。我们总结了 miRNA 在疟疾感染过程中的最新认识。miRNAs 也可以用作生物标志物，初步研究已经揭示了它们在诊断和管理疟疾等各种疾病方面的潜力。
