Lomaeva Iuliia, Aghajanyan Anna, Dzhaparidze Liudmila, Gigani Olga Borisovna, Tskhovrebova Leila V, Gigani Olga Olegovna, Popadyuk Valentin I
Department of Otolaryngology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Medical Clinic "Viterra", 117279 Moscow, Russia.
Life (Basel). 2022 Feb 10;12(2):266. doi: 10.3390/life12020266.
Adenoid hypertrophy (AH) is considered one of the most common diseases in the ear, nose and throat (ENT) practice. The cause of adenoid hypertrophy in children is still unknown. The main aim of the current study was to investigate (interleukin 10) gene polymorphisms and human herpesviruses 6 (HHV6), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) infections in children with AH. A total of 106 children with adenoid hypertrophy and 38 healthy children aged 2-11 years were included in this study. All children with adenoid hypertrophy were divided into three subgroups depending on the adenoid size. The viruses were determined via quantitative real-time polymerase chain reaction (PCR) using commercially available kits (QIAGEN, Germany). HHV6 was more frequently detected in patients with AH compared with CMV and EBV. Among the three subgroups of children with AH, HH6 and EBV were prevalent in the children with the largest adenoid size. The frequency of genotype GG tended to be higher in the control group of children. We found significantly higher frequencies of the G allele and GG and GA genotypes for rs1800896 in the subgroup of children with the smallest size of adenoid compared with other subgroups. In conclusion, HHV6 and EBV infection could contribute to the adenoid size. The genotype GG for rs1800896 could contribute to the resistance to adenoid hypertrophy and the spread of the adenoid tissue.
腺样体肥大（AH）被认为是耳鼻喉科（ENT）临床中最常见的疾病之一。儿童腺样体肥大的病因尚不清楚。本研究的主要目的是调查腺样体肥大儿童的白细胞介素10（IL-10）基因多态性以及人类疱疹病毒6型（HHV6）、巨细胞病毒（CMV）和爱泼斯坦-巴尔病毒（EBV）感染情况。本研究共纳入106例2至11岁的腺样体肥大儿童和38例健康儿童。所有腺样体肥大儿童根据腺样体大小分为三个亚组。使用市售试剂盒（德国QIAGEN公司）通过定量实时聚合酶链反应（PCR）检测病毒。与CMV和EBV相比，HHV6在腺样体肥大患者中更频繁被检测到。在腺样体肥大儿童的三个亚组中，HHV6和EBV在腺样体最大的儿童中最为普遍。基因型GG在儿童对照组中的频率往往更高。我们发现，与其他亚组相比，腺样体最小的儿童亚组中rs1800896的G等位基因以及GG和GA基因型的频率显著更高。总之，HHV6和EBV感染可能与腺样体大小有关。rs1800896的基因型GG可能有助于抵抗腺样体肥大以及腺样体组织的增生。
