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高压氧疗法治疗轻中度牙周病的临床评估:一项简单随机试验。

Clinical Assessment of the Hyperbaric Oxygen Therapy Efficacy in Mild to Moderate Periodontal Affections: A Simple Randomised Trial.

机构信息

Faculty of Dental Medicine, Titu Maiorescu University of Bucharest, 031593 Bucharest, Romania.

Faculty of Dental Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.

出版信息

Medicina (Kaunas). 2022 Feb 4;58(2):234. doi: 10.3390/medicina58020234.

DOI:10.3390/medicina58020234
PMID:35208561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8875551/
Abstract

Gum disease represents the condition due to the dental plaque and dental calculus deposition on the surfaces of the teeth, followed by ulterior destruction of the periodontal tissues through the host reaction to the pathogenic microorganisms. The aim of study was to present aspects regarding the efficacy of hyperbaric oxygen therapy (HBOT) as an adjuvant therapy for the treatment of periodontal disease, started from the already certified benefits of HBOT in the general medicine specialties. The participant patients in this study (71) required and benefited from specific periodontal disease treatments. All patients included in the trial benefited from the conventional therapy of full-mouth scaling and root planing (SRP) within 24 h. HBOT was performed on the patients of the first group (31), in 20 sessions, of one hour. The patients of the control group (40) did not benefit from HBO therapy. At the end of study, the included patients in HBOT group presented significantly better values of oral health index (OHI-S), sulcus bleeding index (SBI), dental mobility (DM), and periodontal pocket depth (PD) than the patients of the control group. HBOT had beneficial effects on the oral and general health of all patients, because in addition to the positive results in periodontal therapy, some individual symptoms of the patients diminished or disappeared upon completion of this adjuvant therapy.

摘要

牙周病是由于牙菌斑和牙石在牙齿表面沉积,进而通过宿主对病原微生物的反应导致牙周组织进一步破坏而引起的疾病。本研究旨在介绍高压氧治疗(HBOT)作为牙周病辅助治疗的疗效,从 HBOT 在一般医学专业中已被证实的益处开始。

本研究的参与者(71 人)需要并受益于特定的牙周病治疗。所有入组患者在 24 小时内均接受了全口洁治和根面平整(SRP)的常规治疗。第一组(31 人)患者接受了 20 次、每次 1 小时的 HBOT。对照组(40 人)患者未接受 HBO 治疗。

研究结束时,HBOT 组患者的口腔健康指数(OHI-S)、龈沟出血指数(SBI)、牙齿松动度(DM)和牙周袋深度(PD)的评分显著优于对照组患者。HBOT 对所有患者的口腔和整体健康都有有益的影响,因为除了牙周治疗的积极结果外,一些患者的个别症状在完成辅助治疗后减轻或消失。

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Current Concepts in the Management of Periodontitis.牙周炎治疗的现状。
Int Dent J. 2021 Dec;71(6):462-476. doi: 10.1111/idj.12630. Epub 2021 Feb 19.
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Oxygen: A Stimulus, Not "Only" a Drug.氧气:一种刺激物,而不只是一种药物。
具有控制氧释放的透明质酸基分散体用于增强牙周组织工程。
Int J Mol Sci. 2023 Mar 21;24(6):5936. doi: 10.3390/ijms24065936.
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Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats.库帕巴在诱导大鼠牙周炎模型中对牙槽骨损伤的生物学活性。
Molecules. 2022 Sep 23;27(19):6255. doi: 10.3390/molecules27196255.
Medicina (Kaunas). 2021 Oct 25;57(11):1161. doi: 10.3390/medicina57111161.
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