Department of Morphological Sciences, Iuliu Hațieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
Department of Neurosurgery, Iuliu Hațieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
Medicina (Kaunas). 2022 Feb 20;58(2):319. doi: 10.3390/medicina58020319.
Glioblastoma multiforme (GBM) is one of the deadliest brain tumors. Current standard therapy includes tumor resection surgery followed by radiotherapy and chemotherapy. Due to the tumors invasive nature, recurrences are almost a certainty, giving the patients after diagnosis only a 12-15 months average survival time. Therefore, there is a dire need of finding new therapies that could potentially improve patient outcomes. Ferroptosis is a newly described form of cell death with several implications in cancer, among which GBM. Agents that target different molecules involved in ferroptosis and that stimulate this process have been described as potentially adjuvant anti-cancer treatment options. In GBM, ferroptosis stimulation inhibits tumor growth, improves patient survival, and increases the efficacy of radiation and chemotherapy. This review provides an overview of the current knowledge regarding ferroptosis modulation in GBM.
胶质母细胞瘤（GBM）是最致命的脑肿瘤之一。目前的标准治疗包括肿瘤切除术，然后进行放疗和化疗。由于肿瘤的侵袭性，复发几乎是必然的，这使得患者诊断后的平均存活时间仅为 12-15 个月。因此，迫切需要寻找新的治疗方法，以提高患者的治疗效果。铁死亡是一种新描述的细胞死亡形式，在癌症中有多种意义，包括 GBM。靶向铁死亡过程中涉及的不同分子并刺激这一过程的药物已被描述为潜在的辅助抗癌治疗选择。在 GBM 中，铁死亡刺激可抑制肿瘤生长，提高患者生存率，并增加放疗和化疗的疗效。这篇综述概述了目前关于 GBM 中铁死亡调节的知识。
