Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
Molecules. 2022 Feb 21;27(4):1447. doi: 10.3390/molecules27041447.
This study was designed to investigate the effects of polysaccharide-rich red algae () hot-water extracts (GHE) on lipid and glucose metabolism in rats with streptozotocin (STZ)/nicotinamide (NA)-induced diabetes. Rats were divided into three groups: NC-normal control group), DM-diabetic group, and DG-diabetic group supplemented with GHE (5%). The experimental diet and drinking water were available ad libitum for 10 weeks. After the 10-week feeding duration, the body weight, liver weight, total adipose tissue weight, and hepatic TBARS and cholesterol levels were significantly increased, and hepatic glycogen content and adipose lipolysis rate were significantly decreased in the DM group, which could be effectively reversed by supplementation of GHE. However, GHE supplementation could not improve the glucose intolerance in DM rats. It was interesting to note that GHE supplementation could decrease the liver glucose-6-phosphotase activity, which was increased in DM rats. Taken together, these results suggested that GHE feeding may ameliorate abnormal hepatic lipid metabolism, but not glucose intolerance, in diabetic rats induced by STZ/NA.
本研究旨在探讨富多糖红藻（）热水提取物（GHE）对链脲佐菌素（STZ）/烟酰胺（NA）诱导的糖尿病大鼠脂类和葡萄糖代谢的影响。大鼠分为三组：NC-正常对照组）、DM-糖尿病组和 DG-糖尿病组补充 GHE（5%）。实验饮食和饮用水可自由获取 10 周。经过 10 周的喂养期后，DM 组大鼠体重、肝重、总脂肪组织重量以及肝 TBARS 和胆固醇水平显著升高，肝糖原含量和脂肪分解率显著降低，GHE 补充可有效逆转这种情况。然而，GHE 补充不能改善 DM 大鼠的葡萄糖耐量。有趣的是，GHE 补充可降低 DM 大鼠中升高的肝葡萄糖-6-磷酸酶活性。综上所述，这些结果表明，GHE 喂养可能改善 STZ/NA 诱导的糖尿病大鼠异常的肝脂质代谢，但不能改善葡萄糖不耐受。
