Department of Biochemistry, 48058Umm Al-Qura University, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt.
J Int Med Res. 2022 Feb;50(2):3000605221076975. doi: 10.1177/03000605221076975.
To determine the prevalence of infection in a Saudi Arabian population and its association with the body mass index (BMI) and serum 8-hydroxy deoxyguanine (8-OHdG) levels as biomarker for oxidative stress.
This cross-sectional study enrolled patients that had experienced epigastric discomfort or dyspepsia for > 1 month and had undergone diagnostic upper endoscopy. Patients with a body mass index (BMI) ≥30 kg/m were defined as obese. The presence of anti- antibodies was confirmed using an immunoglobulin G (IgG) antibody enzyme-linked immunosorbent assay. The levels of 8-OHdG were measured using a competitive inhibition enzyme immunoassay.
A total of 298 patients were enrolled in the study. Of these, 186 (62.4%) patients were -positive and 112 (37.6%) patients were -negative. The mean ± SD age of the overall study cohort was 47.17 ± 9.27 years. The -positive patients had significantly higher levels of IgG antibodies than -negative patients. prevalence linearly correlated with BMI quantile. The 8-OHdG levels were strongly associated with the BMI of the patients in the -positive group.
Obese individuals exhibited higher prevalence than individuals with a lean BMI (BMI < 25.00 kg/m).
确定感染在沙特阿拉伯人群中的流行情况及其与体重指数（BMI）和血清 8-羟基脱氧鸟苷（8-OHdG）水平的关系，后者是氧化应激的生物标志物。
本横断面研究纳入了因上腹不适或消化不良超过 1 个月且接受过诊断性上内窥镜检查的患者。BMI≥30kg/m 的患者被定义为肥胖。使用 IgG 抗体酶联免疫吸附试验（ELISA）确认抗抗体的存在。使用竞争性抑制酶免疫测定法测量 8-OHdG 的水平。
共纳入 298 例患者。其中，186 例（62.4%）患者为阳性，112 例（37.6%）患者为阴性。总体研究队列的平均年龄（SD）为 47.17±9.27 岁。阳性患者的 IgG 抗体水平明显高于阴性患者。阳性患者的 患病率与 BMI 分位数呈线性相关。8-OHdG 水平与阳性组患者的 BMI 密切相关。
肥胖个体的 感染患病率高于 BMI 正常（BMI＜25.00kg/m）个体。
