Izic Belkisa, Custovic Amer, Caluk Selma, Fejzic Hanifa, Kundalic Broza Saric, Husejnovic Maida Sljivic
Clinic for Radiology and Nuclear medicine, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
Clinic for Epidemiology, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
Mater Sociomed. 2021 Dec;33(4):288-292. doi: 10.5455/msm.2021.33.288-292.
Bosnia and Herzegovina (B&H) is one of the countries of Southeast Europe with the lack of data about chronic autoimmune thyroid diseases (CAITD) epidemiology.
This research aimed to assess incidence of CAITD in the Tuzla Canton of B&H during a 6-year period (2015-2020).
We retrospectively evaluated 82,000 hospital records of inpatients and outpatients with possible thyroid symptoms residing in Tuzla Canton of B&H (total of 445,028 inhabitants). The study included patients with laboratory and clinical proof of autoimmune thyroid diseases (AITD). Incidence rates were calculated with age standardisation using European standard population. Trends in incidence were evaluated as moving three-year averages.
During the observed period, 1875 patients satisfied the diagnostic criteria for CAITD with male to female ratio of 1: 8.01. Median age of all cases was 46 years (interquartile range: 31 to 61) and women and men were on average the same age at the time of diagnosis. The overall standardized incidence was found to be 71.25 per 105 (%95 CI=63.36-79.15). The overall standardized incidence in men was 16.25 per 105 and 123.74 per 105 in women. In the end of the observed period, AITD prevalence was 427.52 per 105 (% 95 CI=408.17-446.87).
There was a slight decline of incidence in our region during the observed period. This decrease might be the result of combination of various factors, mainly the Corona epidemics outbreak and emigration. On the basis of the lower incidence rate in the Tuzla Canton, one can assume that iodine prophylaxis carried out in order to eradicate goitre had satisfied expectations because there had not been any enormous increase in patients with AITD.
波斯尼亚和黑塞哥维那（波黑）是东南欧国家之一，缺乏慢性自身免疫性甲状腺疾病（CAITD）流行病学数据。
本研究旨在评估波黑图兹拉州6年期间（2015 - 2020年）CAITD的发病率。
我们回顾性评估了波黑图兹拉州（共445,028名居民）82,000例有甲状腺症状的住院和门诊患者的医院记录。该研究纳入了有自身免疫性甲状腺疾病（AITD）实验室和临床证据的患者。发病率采用欧洲标准人群进行年龄标准化计算。发病率趋势以三年移动平均值进行评估。
在观察期内，1875例患者符合CAITD诊断标准，男女比例为1 : 8.01。所有病例的中位年龄为46岁（四分位间距：31至61岁），女性和男性在诊断时平均年龄相同。总体标准化发病率为每10⁵人口71.25例（95%可信区间 = 63.36 - 79.15）。男性总体标准化发病率为每10⁵人口16.25例，女性为每10⁵人口123.74例。在观察期结束时，AITD患病率为每10⁵人口427.52例（95%可信区间 = 408.17 - 446.87）。
在观察期内我们地区的发病率略有下降。这种下降可能是多种因素综合作用的结果，主要是新冠疫情爆发和移民。基于图兹拉州较低的发病率，可以推测为消除甲状腺肿而进行的碘预防达到了预期效果，因为AITD患者没有出现大幅增加。
