Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin 150030, People's Republic of China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, People's Republic of China.
J Nat Prod. 2022 Apr 22;85(4):1167-1173. doi: 10.1021/acs.jnatprod.1c00820. Epub 2022 Feb 25.
A chemical investigation of sp. Hu186 afforded two known quinone antibiotics, sarubicin A () and sarubicin B (), together with three unusual variants, sarubicinols A-C (-), and two new 1,4-naphthoquinone metabolites, sarubicin B () and sarubicin B (). Compounds - possess a rare 2-oxabicyclo [2.2.2] substructure and a benzoxazole ring system. Their structures were elucidated using 1D and 2D nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data. The absolute configurations of the side-chain moieties in and were solved by electronic circular dichroism calculations. Compounds - showed moderate cytotoxic activity against four tumor cell lines.
对 sp. Hu186 的化学研究提供了两种已知的醌类抗生素，沙柔比星 A（）和沙柔比星 B（），以及三种不寻常的变体，沙柔比星醇 A-C（-），和两种新的 1,4-萘醌代谢物，沙柔比星 B（）和沙柔比星 B（）。化合物 - 具有罕见的 2-氧杂双环[2.2.2]亚结构和苯并恶唑环系统。它们的结构通过 1D 和 2D 核磁共振和高分辨率电喷雾电离质谱数据阐明。通过电子圆二色性计算确定了化合物 和 中侧链部分的绝对构型。化合物 - 对四种肿瘤细胞系表现出中等的细胞毒性活性。
