• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

具有显著抗癌活性的新型硒化合物的药学及安全性评价

Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity.

作者信息

Marć Małgorzata Anna, Domínguez-Álvarez Enrique, Latacz Gniewomir, Doroz-Płonka Agata, Sanmartín Carmen, Spengler Gabriella, Handzlik Jadwiga

机构信息

Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.

Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006 Madrid, Spain.

出版信息

Pharmaceutics. 2022 Feb 6;14(2):367. doi: 10.3390/pharmaceutics14020367.

DOI:10.3390/pharmaceutics14020367
PMID:35214099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8875489/
Abstract

Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive activities of a cyclic selenoanhydride and of a series of selenoesters. Some of these selenium derivatives demonstrated multidrug resistance (MDR)-reversing activity in different resistant cancer cell lines. Thus, the aim of this study was to evaluate the pharmaceutical and safety profiles of these selected selenocompounds using alternative methods in silico and in vitro. One of the main tasks of this work was to determine both the physicochemical properties and metabolic stability of these selenoesters. The obtained results proved that these tested selenocompounds could become potential candidates for novel and safe anticancer drugs with good ADMET parameters. The most favorable selenocompounds turned out to be the phthalic selenoanhydride (), two ketone-containing selenoesters with a 4-chlorophenyl moiety ( and ), and a symmetrical selenodiester with a pyridine ring and two selenium atoms ().

摘要

先前的研究报道了一种环状硒酸酐和一系列硒酯具有强大且选择性的细胞毒性、促凋亡和化学预防活性。其中一些硒衍生物在不同的耐药癌细胞系中表现出多药耐药（MDR）逆转活性。因此，本研究的目的是使用计算机模拟和体外替代方法评估这些选定硒化合物的药学和安全性概况。这项工作的主要任务之一是确定这些硒酯的物理化学性质和代谢稳定性。所得结果证明，这些测试的硒化合物可能成为具有良好药物代谢动力学（ADMET）参数的新型安全抗癌药物的潜在候选物。最有利的硒化合物是邻苯二甲酸硒酸酐（）、两种含有4-氯苯基部分的含酮硒酯（和）以及一种带有吡啶环和两个硒原子的对称硒二酯（）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/a8d296e91982/pharmaceutics-14-00367-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/7c7ef9c0df5d/pharmaceutics-14-00367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/767b7d9a4689/pharmaceutics-14-00367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/39d4330a63e8/pharmaceutics-14-00367-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/441ee096cb91/pharmaceutics-14-00367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/b98730bef103/pharmaceutics-14-00367-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/c527b35513e7/pharmaceutics-14-00367-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/86e13121d0c4/pharmaceutics-14-00367-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/d17caf96346f/pharmaceutics-14-00367-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/8b1d7073fe0a/pharmaceutics-14-00367-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/8639a4d6726a/pharmaceutics-14-00367-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/a8d296e91982/pharmaceutics-14-00367-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/7c7ef9c0df5d/pharmaceutics-14-00367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/767b7d9a4689/pharmaceutics-14-00367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/39d4330a63e8/pharmaceutics-14-00367-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/441ee096cb91/pharmaceutics-14-00367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/b98730bef103/pharmaceutics-14-00367-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/c527b35513e7/pharmaceutics-14-00367-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/86e13121d0c4/pharmaceutics-14-00367-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/d17caf96346f/pharmaceutics-14-00367-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/8b1d7073fe0a/pharmaceutics-14-00367-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/8639a4d6726a/pharmaceutics-14-00367-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/409a/8875489/a8d296e91982/pharmaceutics-14-00367-g010.jpg

相似文献

1
Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity.具有显著抗癌活性的新型硒化合物的药学及安全性评价
Pharmaceutics. 2022 Feb 6;14(2):367. doi: 10.3390/pharmaceutics14020367.
2
Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells.对称硒酯对结肠腺癌细胞多药耐药性的逆转作用
Pharmaceutics. 2023 Feb 11;15(2):610. doi: 10.3390/pharmaceutics15020610.
3
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.鉴定具有逆转癌症多药耐药性的潜在特性的含硒化合物。
Bioorg Med Chem Lett. 2016 Jun 15;26(12):2821-2824. doi: 10.1016/j.bmcl.2016.04.064. Epub 2016 Apr 22.
4
Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.硒酯和硒酸酐作为新型多药耐药逆转剂：在结肠癌多药耐药细胞系中的验证研究。
Bioorg Med Chem Lett. 2017 Feb 15;27(4):797-802. doi: 10.1016/j.bmcl.2017.01.033. Epub 2017 Jan 13.
5
Cyano- and Ketone-Containing Selenoesters as Multi-Target Compounds against Resistant Cancers.含氰基和酮基的硒酸酯作为抗耐药癌症的多靶点化合物
Cancers (Basel). 2021 Sep 11;13(18):4563. doi: 10.3390/cancers13184563.
6
Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance.酮基和氰基硒酸酯用于克服外排泵、群体感应和生物膜介导的耐药性。
Antibiotics (Basel). 2020 Dec 11;9(12):896. doi: 10.3390/antibiotics9120896.
7
Antitumor Activity of Symmetrical Selenoesters in Doxorubicin Resistant Breast Cancer.对称硒酯类化合物在多柔比星耐药乳腺癌中的抗肿瘤活性。
Anticancer Res. 2023 Nov;43(11):4865-4872. doi: 10.21873/anticanres.16683.
8
Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity.硒化物和二硒化物：抗癌和化学预防活性的综述。
Molecules. 2018 Mar 10;23(3):628. doi: 10.3390/molecules23030628.
9
Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors.硒化合物作为新型抗菌剂和细菌外排泵抑制剂。
Molecules. 2019 Apr 16;24(8):1487. doi: 10.3390/molecules24081487.
10
Biofilm Eradication by Symmetrical Selenoesters for Food-Borne Pathogens.用于食源性病原体的对称硒酯对生物膜的根除作用
Microorganisms. 2020 Apr 15;8(4):566. doi: 10.3390/microorganisms8040566.

引用本文的文献

1
A Comprehensive Review of Magnetic Nanocatalysts for C-S, C-Se Bond Formation.用于碳-硫、碳-硒键形成的磁性纳米催化剂综述
ChemistryOpen. 2025 Sep;14(9):e202500041. doi: 10.1002/open.202500041. Epub 2025 Mar 27.
2
Short Communication: Novel Di- and Triselenoesters as Effective Therapeutic Agents Inhibiting Multidrug Resistance Proteins in Breast Cancer Cells.短篇通讯：新型二硒和三硒酯作为有效的治疗乳腺癌细胞多药耐药蛋白的药物。
Int J Mol Sci. 2024 Sep 8;25(17):9732. doi: 10.3390/ijms25179732.
3
Evaluation of novel compounds as anti-bacterial or anti-virulence agents.

本文引用的文献

1
Antitumor Effects of Selenium.硒的抗肿瘤作用。
Int J Mol Sci. 2021 Oct 31;22(21):11844. doi: 10.3390/ijms222111844.
2
Small molecule selenium-containing compounds: Recent development and therapeutic applications.小分子含硒化合物：最新进展及治疗应用。
Eur J Med Chem. 2021 Nov 5;223:113621. doi: 10.1016/j.ejmech.2021.113621. Epub 2021 Jun 12.
3
Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity.硒作为人类饮食中的生物活性微量营养素及其抗癌化学预防活性。
评估新型化合物作为抗菌或抗毒剂的效果。
Front Cell Infect Microbiol. 2024 Mar 6;14:1370062. doi: 10.3389/fcimb.2024.1370062. eCollection 2024.
4
The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries.邻苯二甲酸硒酐降低大鼠血压和离体肠系膜、股动脉和肾动脉张力。
Molecules. 2023 Jun 17;28(12):4826. doi: 10.3390/molecules28124826.
5
Relationships between Molecular Characteristics of Novel Organic Selenium Compounds and the Formation of Sulfur Compounds in Selenium Biofortified Kale Sprouts.新型有机硒化合物的分子特性与富硒羽衣甘蓝芽中硫化合物形成的关系。
Molecules. 2023 Feb 22;28(5):2062. doi: 10.3390/molecules28052062.
6
Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells.对称硒酯对结肠腺癌细胞多药耐药性的逆转作用
Pharmaceutics. 2023 Feb 11;15(2):610. doi: 10.3390/pharmaceutics15020610.
7
Olaparib Conjugates with Selenopheno[3,2-]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance.奥拉帕尼与硒苯并[3,2 -]喹啉酮的缀合物抑制PARP1并逆转ABCB1相关的多药耐药性。
Pharmaceutics. 2022 Nov 23;14(12):2571. doi: 10.3390/pharmaceutics14122571.
8
Novel Selenoesters as a Potential Tool in Triple-Negative Breast Cancer Treatment.新型硒酯作为三阴性乳腺癌治疗的潜在工具。
Cancers (Basel). 2022 Sep 2;14(17):4304. doi: 10.3390/cancers14174304.
Nutrients. 2021 May 13;13(5):1649. doi: 10.3390/nu13051649.
4
Docking and molecular dynamics predicted B-DNA and dihydropyrimidinone selenoesters interactions elucidating antiproliferative effects on breast adenocarcinoma cells.对接和分子动力学预测 B-DNA 与二氢嘧啶酮硒代酯的相互作用，阐明对乳腺癌细胞的抗增殖作用。
J Biomol Struct Dyn. 2022 Nov;40(18):8261-8273. doi: 10.1080/07391102.2021.1910569. Epub 2021 Apr 13.
5
An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells.深入了解咪唑烷-2,4-二酮的 5-螺环芳基衍生物的结构，这是一组新的非常有效的 T 淋巴细胞瘤细胞多药耐药性抑制剂。
Bioorg Chem. 2021 Apr;109:104735. doi: 10.1016/j.bioorg.2021.104735. Epub 2021 Feb 18.
6
Selenium Compounds as Novel Potential Anticancer Agents.硒化合物作为新型潜在的抗癌剂。
Int J Mol Sci. 2021 Jan 20;22(3):1009. doi: 10.3390/ijms22031009.
7
Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance.酮基和氰基硒酸酯用于克服外排泵、群体感应和生物膜介导的耐药性。
Antibiotics (Basel). 2020 Dec 11;9(12):896. doi: 10.3390/antibiotics9120896.
8
New Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity towards Colon Cancer.新型含甲基硒代阿司匹林类似物的抗癌活性研究——针对结肠癌。
Int J Mol Sci. 2020 Nov 27;21(23):9017. doi: 10.3390/ijms21239017.
9
Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides.硒酯和硒酐的抗病毒、抗菌和抗生物膜活性。
Molecules. 2019 Nov 22;24(23):4264. doi: 10.3390/molecules24234264.
10
Selenium intake, status, and health: a complex relationship.硒的摄入、状态和健康：复杂的关系。
Hormones (Athens). 2020 Mar;19(1):9-14. doi: 10.1007/s42000-019-00125-5. Epub 2019 Aug 6.